4-(4-Pyridinyl)thiazole-2-thiol

Base Information

• Chemical Name: 4-(4-Pyridinyl)thiazole-2-thiol
• CAS No.: 77168-63-9
• Molecular Formula: C8H6N2S2
• Molecular Weight: 194.281
• Hs Code.: 2934100090
• Mol file: 77168-63-9.mol

Synonyms:2-mercapto-4-(4-pyridyl)thiazole;4-(pyridin-4-yl)-1,3-thiazole-2-thiol;4-(4-Pyridinyl)thiazole-2-thiol;4-(4-pyridyl)thiazole-2-thiol;[4-(4-pyridyl)-1,3-thiazol-2-yl]thiol;4-(4-pyridyl)-1,3-thiazole-2-thiol;2-mercapto-4-(pyridine-4-yl)thiazole;

Chemical Property of 4-(4-Pyridinyl)thiazole-2-thiol

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.671
• Boiling Point: 356.135 °C at 760 mmHg
• PKA: 7.01±0.40(Predicted)
• Flash Point: 169.184 °C
• PSA: 92.82000
• Density: 1.356 g/cm³
• LogP: 2.49380
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

4-(4-Pyridinyl)thiazole-2-thiol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4-(4-Pyridinyl)thiazole-2-thiol is a reactant used to synthesize novel thiazolidine derivatives and azetidinone derivatives, which possess antiproliferative activity and inhibitory activity against the proliferation of the MCF-7 breast cancer cell line.

Technology Process of 4-(4-Pyridinyl)thiazole-2-thiol

There total 5 articles about 4-(4-Pyridinyl)thiazole-2-thiol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.2%

4-(pyridin-4-yl)thiazole-2(3H)-thione → [4-(4-pyridyl)-1,3-thiazol-2-yl]thiol (77168-63-9)

Guidance literature:

With acetic acid; for 5h; Reflux;

Reference yield: 82.6%

4-(bromoacetyl)pyridine (6221-13-2) + ammonium dithiocarbamate (513-74-6) → [4-(4-pyridyl)-1,3-thiazol-2-yl]thiol (77168-63-9)

Guidance literature:

at 0 - 25 ℃; for 5h;

Reference yield:

methyl (4-pyridyl) ketone (1122-54-9) → [4-(4-pyridyl)-1,3-thiazol-2-yl]thiol (77168-63-9)

Guidance literature:

Multi-step reaction with 3 steps

1: bromine / tetrachloromethane / 2 h / -5 - 78 °C

2: ethanol / 5 h / 20 °C

3: acetic acid / 5 h / Reflux

With bromine; acetic acid; In tetrachloromethane; ethanol;

upstream raw materials:

methyl (4-pyridyl) ketone

4-(bromoacetyl)pyridine

ammonium dithiocarbamate

Downstream raw materials:

(4R,5S,6S)-6-((R)-1-Hydroxy-ethyl)-4-methyl-7-oxo-3-(4-pyridin-4-yl-thiazol-2-ylsulfanyl)-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-nitro-benzyl ester

4-(2-{[(6R,7R)-2-[(diphenylmethoxy)carbonyl]-8-oxo-7-(2-phenylacetamido)-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]sulfanyl}-1,3-thiazol-4-yl)pyridine

[4-(N-methylpyridinium-4-yl)-1,3-thiazol-2-yl]thiolate

4-(2-mercapto-thiazol-4-yl)-1-methyl-pyridinium toluene-4-sulfonate

Refernces

• 1、 -. "Synthesis method of ceftaroline fosamil intermediate 4-(4'-pyridyl)-1,3-thiazolyl-2-thiol". Paragraph 0013. . Retrieved 2016/11/24.
• 2、 -. "MORPHOLINE COMPOUND". Page/Page column 31. . Retrieved 2010/11/27.