6-(Hydroxymethyl)picolinic acid

Base Information

• Chemical Name: 6-(Hydroxymethyl)picolinic acid
• CAS No.: 1197-10-0
• Molecular Formula: C7H7NO3
• Molecular Weight: 153.137
• Hs Code.: 2933399090
• European Community (EC) Number: 811-322-3
• DSSTox Substance ID: DTXSID80472746
• Nikkaji Number: J2.222.657F
• Wikidata: Q82301858
• Mol file: 1197-10-0.mol

Synonyms:6-(Hydroxymethyl)picolinic acid;1197-10-0;6-Hydroxymethyl-pyridine-2-carboxylic acid;6-(hydroxymethyl)pyridine-2-carboxylic Acid;2-Pyridinecarboxylic acid, 6-(hydroxymethyl)-;L-Lysinebase;6-hydroxymethylpicolinic acid;SCHEMBL347912;DTXSID80472746;SWQMSUWYOLDNBU-UHFFFAOYSA-N;MFCD09032021;AKOS006288879;CS-W022435;DS-0544;AC-20723;TS-02031;2-Pyridinecarboxylicacid,6-(hydroxymethyl)-;AM20061814;FT-0651281;EN300-148780;A892479;J-004180;J-518795

Chemical Property of 6-(Hydroxymethyl)picolinic acid

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 137 °C
• Refractive Index: 1.609
• Boiling Point: 381.235 °C at 760 mmHg
• PKA: 0.96±0.50(Predicted)
• Flash Point: 184.364 °C
• PSA: 70.42000
• Density: 1.405 g/cm³
• LogP: 0.27210
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• XLogP3: -0.1
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 153.042593085
• Heavy Atom Count: 11
• Complexity: 149

Purity/Quality:

98%,99%, ^*data from raw suppliers

6-(Hydroxymethyl)picolinicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=NC(=C1)C(=O)O)CO

Technology Process of 6-(Hydroxymethyl)picolinic acid

There total 14 articles about 6-(Hydroxymethyl)picolinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methyl 6-(hydroxymethyl)pyridine-2-carboxylate (39977-44-1) → 6-(hydroxymethyl)pyridine-2-carboxylic acid (1197-10-0)

Guidance literature:

With water; sodium hydroxide; In methanol; at 100 ℃; for 0.166667h; Microwave irradiation; Inert atmosphere;

DOI:10.1002/chem.201301871

Reference yield: 97.0%

ethyl 6-(hydroxymethyl)pyridine-2-carboxylate (41337-81-9) → 6-(hydroxymethyl)pyridine-2-carboxylic acid (1197-10-0)

Guidance literature:

With sodium hydroxide; for 12h; Ambient temperature;

Reference yield: 97.0%

ethyl 6-(acetyloxymethyl)pyridine-2-carboxylate (41570-99-4) → 6-(hydroxymethyl)pyridine-2-carboxylic acid (1197-10-0)

Guidance literature:

With sodium hydroxide; In ethanol; Ambient temperature;

DOI:10.1002/jhet.5570310635

upstream raw materials:

2,6-Pyridinedicarboxaldehyde

ethyl 6-(hydroxymethyl)pyridine-2-carboxylate

6-carboxy-2-pyridylmethyl α-(N-acetylamino)cinnamate

ethyl 6-(acetyloxymethyl)pyridine-2-carboxylate

Downstream raw materials:

6-hydroxymethyl-2-pyridine carboxylic acid hydrazide

{[2-(acetyloxy)benzoyl]oxy}methyl 6-(hydroxymethyl)pyridine-2-carboxylate

C₄₂H₄₄N₄O₄S₂

Refernces

• 1、 Clausen, Dane J.,Smith, William B.,Haines, Brandon E.,Wiest, Olaf,Bradner, James E.,Williams, Robert M.. "Modular synthesis and biological activity of pyridyl-based analogs of the potent Class i Histone Deacetylase Inhibitor Largazole". . p. 5061 - 5074. Retrieved 2015/08/03.
• 2、 Moehlmann, Lennart,Ludwig, Stefan,Blechert, Siegfried. "NHC-catalysed highly selective aerobic oxidation of nonactivated aldehydes". . p. 602 - 607. Retrieved 2013/04/24.