6-BROMOPYRIDINE-2,3-DIAMINE

Base Information

• Chemical Name: 6-BROMOPYRIDINE-2,3-DIAMINE
• CAS No.: 129012-04-0
• Molecular Formula: C10H8 Cl N . Cl H
• Molecular Weight: 188.027
• Hs Code.: 2933399090
• Mol file: 129012-04-0.mol

Synonyms:Quinaldine,4-chloro-, hydrochloride (7CI); Quinoline, 4-chloro-2-methyl-, hydrochloride(9CI)

Chemical Property of 6-BROMOPYRIDINE-2,3-DIAMINE

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 345.208oC at 760 mmHg
• PKA: 2.65±0.50(Predicted)
• Flash Point: 162.576oC
• PSA: 64.93000
• Density: 1.818g/cm3
• LogP: 2.17090
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

98%,99%, ^*data from raw suppliers

6-Bromopyridine-2,3-diamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-BROMOPYRIDINE-2,3-DIAMINE

There total 7 articles about 6-BROMOPYRIDINE-2,3-DIAMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

6-bromo-3-nitro-pyridin-2-ylamine (84487-04-7) → 2,3-Diamino-6-bromopyridine (129012-04-0)

Guidance literature:

With acetic acid; zinc; In methanol; ethanol; at 0 - 20 ℃; for 15h;

Reference yield:

6-bromo-N-(4-methoxybenzyl)pyridine-2,3-diamine (1254171-35-1) → 2,3-Diamino-6-bromopyridine (129012-04-0)

Guidance literature:

6-bromo-N-(4-methoxybenzyl)pyridine-2,3-diamine; With trifluoroacetic acid; at 85 ℃; for 2h;

With sodium hydrogencarbonate; In water;

Reference yield:

6-bromo-2-nitropyridin-3-amine (1211333-10-6) → 2,3-Diamino-6-bromopyridine (129012-04-0)

Guidance literature:

With tin(ll) chloride; In ethanol; water; for 1h; Inert atmosphere; Reflux;

DOI:10.1016/j.bioorg.2020.104502

upstream raw materials:

6-bromo-3-nitro-pyridin-2-ylamine

iron

6-bromo-N-(4-methoxybenzyl)pyridine-2,3-diamine

2,6-dibromo-3-nitropyridine

Downstream raw materials:

4-(5-Bromo-1H-imidazo[4,5-b]pyridin-2-yl)-phenol

N-(2-amino-6-bromopyridin-3-yl)-2-(2-chloro-6-fluorophenyl)-1H-imidazole-4-carboxamide

Refernces

• 1、 -. "HETEROCYCLIC COMPOUNDS AND USE THEREOF AS MODULATORS OF TYPE III RECEPTOR TYROSINE KINASES". Paragraph 0578. . Retrieved 2016/08/03.
• 2、 -. "NOVEL COMPOUNDS AS ANTAGONISTS OR INVERSE AGONISTS FOR OPIOID RECEPTORS". Page/Page column 91. . Retrieved 2010/09/07.