Pyridine, 2-chloro-5-iodo-4-methyl-

Base Information

• Chemical Name: Pyridine, 2-chloro-5-iodo-4-methyl-
• CAS No.: 550347-54-1
• Molecular Formula: C6H5FIN
• Molecular Weight: 237.01300
• Hs Code.: 2933399090
• Mol file: 550347-54-1.mol

Synonyms:2-chloro-5-iodo-4-methylpyridine;

Chemical Property of Pyridine, 2-chloro-5-iodo-4-methyl-

Chemical Property:

• Boiling Point: 279.4±35.0 °C(Predicted)
• PKA: -1.20±0.10(Predicted)
• PSA: 12.89000
• Density: 1.906±0.06 g/cm3(Predicted)
• LogP: 2.13370
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

99% ^*data from raw suppliers

2-Chloro-5-iodo-4-methylpyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-Chloro-5-iodo-4-methylpyridine can be used as reactant/reagent of synthesis of conformationally constrained spirodihydrofuropyridine analogs of epibatidine.

Technology Process of Pyridine, 2-chloro-5-iodo-4-methyl-

There total 3 articles about Pyridine, 2-chloro-5-iodo-4-methyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

5-iodo-4-methylpyridin-2-ylamine (356561-08-5) → 2-chloro-5-iodo-4-methylpyridine (550347-54-1)

Guidance literature:

With hydrogenchloride; sodium nitrite; at 20 ℃;

DOI:10.1016/S0040-4039(03)00395-2

Reference yield:

4-bromomethyl-2-chloro-5-iodopyridine → (2-chloro-5-iodopyridin-4-yl)methanol + 2-chloro-5-iodo-4-methylpyridine (550347-54-1)

Guidance literature:

With water; calcium carbonate; In 1,4-dioxane; for 10h; Reflux;

Reference yield:

2-Amino-4-methylpyridine (695-34-1) → 2-chloro-5-iodo-4-methylpyridine (550347-54-1)

Guidance literature:

Multi-step reaction with 2 steps

1: I₂; H₅IO₆; H₂SO₄ / H₂O; acetic acid / 80 °C

2: 78 percent / NaNO₂; HCl / 20 °C

With hydrogenchloride; sulfuric acid; iodine; periodic acid; sodium nitrite; In water; acetic acid;

DOI:10.1016/S0040-4039(03)00395-2

upstream raw materials:

5-iodo-4-methylpyridin-2-ylamine

2-Amino-4-methylpyridine

Downstream raw materials:

1-(6'-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-1'H-spiro[azetidine-3,3'-furo[3,4-c]pyridine]-1-yl)-2-(methylsulfonyl)ethanone

tert-butyl 6'-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-1'H-spiro[azetidine-3,3'-furo[3,4-c]pyridine]-1-carboxylate

6'-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-1'H-spiro[azetidine-3,3'-furo[3,4-c]pyridine] trifluoroacetic acid salt

Refernces

• 1、 Abe, Hideki,Arai, Yumiko,Aoyagi, Sakae,Kibayashi, Chihiro. "Synthesis of conformationally constrained spirodihydrofuropyridine analogues of epibatidine". . p. 2971 - 2973. Retrieved 2007/10/03.