2-Chloro-3,5-dimethylpyrazine

Base Information

• Chemical Name: 2-Chloro-3,5-dimethylpyrazine
• CAS No.: 38557-72-1
• Molecular Formula: C6H7ClN2
• Molecular Weight: 142.588
• Hs Code.: 2933990090
• European Community (EC) Number: 696-037-0
• DSSTox Substance ID: DTXSID70470352
• Mol file: 38557-72-1.mol

Synonyms:2-chloro-3,5-dimethylpyrazine;38557-72-1;2-chloro 3,5-dimethyl pyarazine;MFCD00126945;2-chloro-3,5-dimethyl-pyrazine;Pyrazine, 2-chloro-3,5-dimethyl-;SCHEMBL841270;3,5-dimethyl-2-chloropyrazine;2-chloro 3,5-dimethyl pyrazine;2-chloro-3,5-dimethyl pyrazine;DTXSID70470352;BTGGHNHGPURMEO-UHFFFAOYSA-N;BCP23123;AKOS006345707;AB03542;CS-W002391;DS-1487;PS-3537;2-Chloro-3 pound not5-dimethylpyrazine;SY023945;AM20070351;C3118;FT-0688735;EN300-223900;A824192;Q-103290;Z1201619176

Chemical Property of 2-Chloro-3,5-dimethylpyrazine

Chemical Property:

• Vapor Pressure: 0.904mmHg at 25°C
• Refractive Index: 1.526
• Boiling Point: 186.588 °C at 760 mmHg
• PKA: 0.47±0.10(Predicted)
• Flash Point: 83.142 °C
• PSA: 25.78000
• Density: 1.184 g/cm³
• LogP: 1.74680
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Solubility.: Chloroform, Methanol (Slightly)
• XLogP3: 1.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 142.0297759
• Heavy Atom Count: 9
• Complexity: 97.1

Purity/Quality:

99% ^*data from raw suppliers

2-Chloro-3,5-dimethylpyrazine ^*data from reagent suppliers

Safty Information:

• Statements: 36/38
• Safety Statements: 23-26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CN=C(C(=N1)C)Cl
• Uses: 2-Chloro-3,5-dimethylpyrazine, is a halogenated pyrazine, that can be used as an intermediates in chemical synthesis.

Technology Process of 2-Chloro-3,5-dimethylpyrazine

There total 4 articles about 2-Chloro-3,5-dimethylpyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,4-dimethyl-2-imidazoline (930-61-0) + chloroform (67-66-3,8013-54-5) → 2,4-dimethylpyrimidine (14331-54-5) + 2,5-dimethyl-pyrazine (123-32-0) + 2,5-dimethyl-3-chloropyrazine (95-89-6) + 2-chloro-3,5-dimethylpyrazine (38557-72-1)

Guidance literature:

at 550 ℃; Yield given. Further byproducts given. Yields of byproduct given. Title compound not separated from byproducts;

DOI:10.1039/P19800001431

Reference yield:

2,4-dimethyl-2-imidazoline (930-61-0) + chloroform (67-66-3,8013-54-5) → 2,5-dimethyl-pyrazine (123-32-0) + 2,5-dimethyl-3-chloropyrazine (95-89-6) + 2-chloro-3,5-dimethylpyrazine (38557-72-1) + 4-chloro-2,5-dimethylpyrimidine (75712-74-2)

Guidance literature:

at 550 ℃; Yield given. Further byproducts given. Yields of byproduct given. Title compound not separated from byproducts;

DOI:10.1039/P19800001431

Reference yield:

2,4-Dimethylimidazole (930-62-1) + chloroform (67-66-3,8013-54-5) → 4-chloro-2,6-dimethylpyrimidine (4472-45-1) + 2,5-dimethyl-3-chloropyrazine (95-89-6) + 2-chloro-3,5-dimethylpyrazine (38557-72-1) + 5-Chloro-2,4-dimethylpyrimidine (75712-73-1)

Guidance literature:

at 550 ℃; Yield given. Further byproducts given. Yields of byproduct given. Title compound not separated from byproducts;

DOI:10.1039/P19800001427

upstream raw materials:

2,4-dimethyl-2-imidazoline

chloroform

2,4-Dimethylimidazole

4-fluoroboronic acid

Downstream raw materials:

3,5-dimethyl-2-(4-phenoxyphenyl)pyrazine

2-amino-3,5-dimethyl pyrazine

3,5-dimethyl-2-(3-diphenylaminophenyl)pyrazine

3,5-imethyl-2-(7-phenylnaphthalen-2-yl)pyrazine

Refernces

• 1、 Busby, Reginald E.,Khan, Mohammad A.,Khan, Mohammad R.,Parrick, John,Shaw, C. J. Granville. "Reactions of Halogenomethanes in the Vapour Phase. Part 5. The Reactions of Imidazolines, Anils, and 1-Methylimidazole with Chloroform at 550 deg C, and a Comparison with their Liquid-Phase Reactions with Trichloroacetate Ion or Hexachloroacetone and Base". . p. 1431 - 1435. Retrieved 2007/10/02.