2-Bromo-3-furoyl chloride

Base Information

• Chemical Name: 2-Bromo-3-furoyl chloride
• CAS No.: 915707-69-6
• Molecular Formula: C₅H₂BrClO₂
• Molecular Weight: 209.427
• Hs Code.: 2932190090
• Mol file: 915707-69-6.mol

Synonyms:2-Bromo-3-furoyl chloride;2-Bromo-3-furoyl chloride 97%;2-Bromofuran-3-carbonyl chloride, 2-Bromo-3-(chlorocarbonyl)furan

Chemical Property of 2-Bromo-3-furoyl chloride

Chemical Property:

• Vapor Pressure: 0.23mmHg at 25°C
• Refractive Index: 1.548
• Boiling Point: 207.1 °C at 760 mmHg
• Flash Point: 79 °C
• PSA: 30.21000
• Density: 1.823 g/cm³
• LogP: 2.42110

Purity/Quality:

99%min. ^*data from raw suppliers

2-Bromo-3-furoylchloride 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C
• Hazard Codes: C

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Bromo-3-furoyl chloride

There total 2 articles about 2-Bromo-3-furoyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-bromofuran-3-carboxylic acid (197846-05-2) → 2-bromofuran-3-carbonyl chloride (915707-69-6)

Guidance literature:

With thionyl chloride; In benzene; for 4h; Heating;

DOI:10.1021/jm970346t

Reference yield:

3-Furoic acid (488-93-7) → 2-bromofuran-3-carbonyl chloride (915707-69-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) LDA, 2.) 1,2-dibromotetrafluoroethane / 1.) THF, n-heptane, -78 deg C, 3 h, 2.) THF, n-heptane, from -78 deg C to RT, 10 h

2: SOCl₂ / benzene / 4 h / Heating

With thionyl chloride; 1,2-dibromo-1,1,2,2-tetrafluoroethane; lithium diisopropyl amide; In benzene;

DOI:10.1021/jm970346t

Reference yield:

2-bromofuran-3-carbonyl chloride (915707-69-6) → 2-(1-Aza-bicyclo[2.2.2]oct-2-en-3-yl)-furan-3-carboxylic acid phenylamide

Guidance literature:

Multi-step reaction with 2 steps

1: Et₃N / benzene / 5 h / Ambient temperature

2: 1.) Pd(PPh₃)4, CuO / 1.) DMF, 100 deg C, 5 min, 2.) DMF, 100 deg C, 7 h

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine; copper(II) oxide; In benzene;

DOI:10.1021/jm970346t

upstream raw materials:

2-bromofuran-3-carboxylic acid

3-Furoic acid

Downstream raw materials:

2-Bromo-furan-3-carboxylic acid phenylamide

Refernces

• 1、 Conde, Nerea,Churruca, Fátima,Sanmartin, Raul,Herrero, María Teresa,Domínguez, Esther. "A further decrease in the catalyst loading for the palladium-catalyzed direct intramolecular arylation of amides and sulfonamides". supporting information. p. 1525 - 1531. Retrieved 2015/05/26.
• 2、 Johansson, Gary. "Antimuscarinic 3-(2-Furanyl)quinuclidin-2-ene derivatives: Synthesis and structure-activity relationships". . p. 3804 - 3819. Retrieved 2007/10/03.