6-Chloro-3-formyl-7-methylchromone

Base Information

• Chemical Name: 6-Chloro-3-formyl-7-methylchromone
• CAS No.: 64481-12-5
• Molecular Formula: C11H7ClO3
• Molecular Weight: 222.628
• Hs Code.: 29329990
• Mol file: 64481-12-5.mol

Synonyms:6-Chloro-7-methyl-3-formylchromone;

Chemical Property of 6-Chloro-3-formyl-7-methylchromone

Chemical Property:

• Vapor Pressure: 5.26E-06mmHg at 25°C
• Melting Point: 183-185 °C (lit.)
• Refractive Index: 1.671
• Boiling Point: 380.9 °C at 760 mmHg
• Flash Point: 171.3 °C
• PSA: 47.28000
• Density: 1.485 g/cm³
• LogP: 2.56730

Purity/Quality:

98%,99%, ^*data from raw suppliers

6-Chloro-3-formyl-7-methylchromone ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 6-Chloro-3-formyl-7-methylchromone is the suitable reagent used in a study to investigate the multidrug resistabnce reversal by some 3- formylchromones in human colon cancer and mouse lymphoma cells transfected with the human MDR1 gene. It is the suitable reagent used in the synthesis of uridine-based library.

Technology Process of 6-Chloro-3-formyl-7-methylchromone

There total 2 articles about 6-Chloro-3-formyl-7-methylchromone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

3-(5-Chloro-2-hydroxy-4-methyl-phenyl)-3-oxo-propionaldehyde + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 6-chloro-7-methyl-4-oxo-4H-chromene-3-carbaldehyde (64481-12-5)

Guidance literature:

With trichlorophosphate; for 24h; Ambient temperature;

Reference yield:

5'-chloro-2'-hydroxy-4'-methyl acetophenone (28480-70-8) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 6-chloro-7-methyl-4-oxo-4H-chromene-3-carbaldehyde (64481-12-5)

Guidance literature:

With trichlorophosphate; at -5 - 0 ℃;

DOI:10.1016/j.bmcl.2014.05.034

Reference yield: 87.0%

6-chloro-7-methyl-4-oxo-4H-chromene-3-carbaldehyde (64481-12-5) + benzil (134-81-6) + m,p-dichloroaniline (95-76-1) → C31H19Cl3N2O2

Guidance literature:

With ammonium cerium (IV) nitrate; ammonium acetate; In ethanol; for 3.5h; Reflux;

DOI:10.1016/j.bmcl.2021.127916

upstream raw materials:

N,N-dimethyl-formamide

5'-chloro-2'-hydroxy-4'-methyl acetophenone

Downstream raw materials:

6-Chloro-2-ethoxy-7-methyl-3-[1-p-tolylamino-meth-(E)-ylidene]-chroman-4-one

6-Chloro-3-[1-(4-chloro-phenylamino)-meth-(E)-ylidene]-2-ethoxy-7-methyl-chroman-4-one

6-Chloro-2-ethoxy-3-[1-(4-methoxy-phenylamino)-meth-(E)-ylidene]-7-methyl-chroman-4-one

6-Chloro-2-ethoxy-7-methyl-3-[1-phenylamino-meth-(E)-ylidene]-chroman-4-one

Refernces

• 1、 Nazreen, Syed,Alam, Mohammad Sarwar,Hamid, Hinna,Yar, Mohammad Shahar,Dhulap, Abhijeet,Alam, Perwez,Pasha,Bano, Sameena,Alam, Mohammad Mahboob,Haider, Saqlain,Kharbanda, Chetna,Ali, Yakub,Pillai. "Thiazolidine-2,4-diones derivatives as PPAR-γ agonists: Synthesis, molecular docking, in vitro and in vivo antidiabetic activity with hepatotoxicity risk evaluation and effect on PPAR-γ gene expression". . p. 3034 - 3042. Retrieved 2014/06/24.