Technology Process of 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-7-hydroxy-2-methylisoquinoline
There total 4 articles about 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-7-hydroxy-2-methylisoquinoline which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
(+)-4-(3,4-dichlorophenyl)-7-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline;
With
hydrogen bromide;
In
acetic acid;
for 8h;
Cooling with ice;
With
sodium hydrogencarbonate; sodium hydroxide;
In
water; acetic acid;
pH=8 - 9;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: sodium tetrahydroborate / methanol / 2 h / 0 °C
2.1: sulfuric acid / dichloromethane; water / 28 h / 0 °C
2.2: pH ~ 9
3.1: Chiralpak AD column / diethylamine; isopropyl alcohol / Resolution of racemate
4.1: hydrogen bromide / water; acetic acid / 8 h / Reflux
With
sodium tetrahydroborate; sulfuric acid; hydrogen bromide;
In
methanol; dichloromethane; water; acetic acid; diethylamine; isopropyl alcohol;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: sodium tetrahydroborate / methanol; water / 2 h / 0 °C
2.1: dichloromethane / 1 h / 0 °C
2.2: 1 h / 0 °C
3.1: sodium tetrahydroborate / methanol / 2 h / 0 °C
4.1: sulfuric acid / dichloromethane; water / 28 h / 0 °C
4.2: pH ~ 9
5.1: Chiralpak AD column / diethylamine; isopropyl alcohol / Resolution of racemate
6.1: hydrogen bromide / water; acetic acid / 8 h / Reflux
With
sodium tetrahydroborate; sulfuric acid; hydrogen bromide;
In
methanol; dichloromethane; water; acetic acid; diethylamine; isopropyl alcohol;