4-methoxy-2-trimethylsilylphenol

Base Information

• Chemical Name: 4-methoxy-2-trimethylsilylphenol
• CAS No.: 85630-29-1
• Molecular Formula: C₁₀H₁₆O₂Si
• Molecular Weight: 196.321
• Mol file: 85630-29-1.mol

Synonyms:4-methoxy-2-trimethylsilylphenol

Chemical Property of 4-methoxy-2-trimethylsilylphenol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-methoxy-2-trimethylsilylphenol

There total 16 articles about 4-methoxy-2-trimethylsilylphenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-TMS-4-methoxyphenol → 4-methoxy-2-trimethylsilylphenol (85630-29-1)

Guidance literature:

With hydrogenchloride; In methanol; dichloromethane; water; at 20 ℃;

DOI:10.1002/anie.201802443

Reference yield: 76.0%

chloro-trimethyl-silane (75-77-4) + 2-bromo-4-methoxyphenol (17332-11-5) → 4-methoxy-2-trimethylsilylphenol (85630-29-1)

Guidance literature:

2-bromo-4-methoxyphenol; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.8h; Inert atmosphere;

chloro-trimethyl-silane; In tetrahydrofuran; hexane; at 25 ℃; for 4h; Inert atmosphere;

DOI:10.1021/jo300290v

Reference yield:

2-bromo-4-methoxyphenol (17332-11-5) + lithium hexamethyldisilazane (4039-32-1) → 4-methoxy-2-trimethylsilylphenol (85630-29-1)

Guidance literature:

In tetrahydrofuran; at 70 ℃; for 2h;

DOI:10.1016/j.tetlet.2019.04.033

upstream raw materials:

2-chloro-5-methoxyphenyltrimethylsilane

acetonitrile

allyl-trimethyl-silane

chloro-trimethyl-silane

Downstream raw materials:

2-trimethylsilyl-4-methoxyacetanilide

3-trimethylsilylanisol

2-(2,2,2-trifluoroethoxy)-5-methoxytrimethylsilylbenzene

4-methoxy-2-(trimethylsilyl)phenyl triflate

Refernces

• 1、 Xu, Youzhi,Wang, Bingzhe,Kaur, Ramandeep,Minameyer, Martin B.,Bothe, Michael,Drewello, Thomas,Guldi, Dirk M.,von Delius, Max. "A Supramolecular [10]CPP Junction Enables Efficient Electron Transfer in Modular Porphyrin–[10]CPP?Fullerene Complexes". . p. 11549 - 11553. Retrieved 2018/09/10.
• 2、 Ting, Chun-Ming,Hsu, Yi-Ling,Liu, Rai-Shung. "Gold-catalyzed isomerization of unactivated allenes into 1,3-dienes under ambient conditions". supporting information; experimental part. p. 6577 - 6579. Retrieved 2012/07/31.