VUF 5667

Base Information

• Chemical Name: VUF 5667
• CAS No.: 251359-78-1
• Molecular Formula: C₂₇H₃₀ClNO
• Molecular Weight: 419.994
• Mol file: 251359-78-1.mol

Synonyms:VUF 5667

Chemical Property of VUF 5667

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of VUF 5667

There total 6 articles about VUF 5667 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

4-(4-chlorophenyl)-4-hydroxypiperidine (39512-49-7) + 1,1-diphenyl-4-chlorobutane (3312-08-1) → VUF 5667 (251359-78-1)

Guidance literature:

With sodium carbonate; sodium iodide; In acetonitrile; Heating;

DOI:10.1021/jm050418d

Reference yield: 8.0%

4-(4-chlorophenyl)-4-hydroxypiperidine (39512-49-7) + 4-methanesulfonyloxy-1,1-diphenylbutane (104675-46-9) → VUF 5667 (251359-78-1)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide;

DOI:10.1021/jm990316l

Reference yield:

benzophenone (119-61-9) → VUF 5667 (251359-78-1)

Guidance literature:

Multi-step reaction with 4 steps

1.1: t-BuOK / tetrahydrofuran / 3 h / 70 °C

1.2: 2.17 g / tetrahydrofuran / 6 h / 70 °C

2.1: 1.31 g / H₂ / 10 percent Pd/C / ethanol / 2585.74 Torr

3.1: 1.32 g / Et₃N / CH₂Cl₂ / 2.5 h / 0 - 20 °C

4.1: 8 percent / diisopropylethylamine / dimethylformamide

With potassium tert-butylate; hydrogen; triethylamine; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; 1.1: Metallation / 1.2: Condensation / 2.1: Hydrogenolysis / 3.1: mesylation / 4.1: Substitution;

DOI:10.1021/jm990316l

upstream raw materials:

4-(4-chlorophenyl)-4-hydroxypiperidine

4-methanesulfonyloxy-1,1-diphenylbutane

1,1-diphenyl-4-chlorobutane

benzophenone

Refernces

• 1、 Ng, Howard P.,Karen, May,Bauman, John G.,Ghannam, Ameen,Islam, Imadul,Liang, Meina,Horuk, Richard,Hesselgesser, Joseph,Snider, R. Michael,Perez, H. Daniel,Morrissey, Michael M.. "Discovery of novel non-peptide CCR1 receptor antagonists". . p. 4680 - 4694. Retrieved 2007/10/03.