(R)-α-cyclopropylbenzyl alcohol

Base Information

• Chemical Name: (R)-α-cyclopropylbenzyl alcohol
• CAS No.: 110548-55-5
• Molecular Formula: C₁₀H₁₂O
• Molecular Weight: 148.205
• Mol file: 110548-55-5.mol

Synonyms:(R)-α-cyclopropylbenzyl alcohol

Chemical Property of (R)-α-cyclopropylbenzyl alcohol

Chemical Property:

Purity/Quality:

Safty Information:

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• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-α-cyclopropylbenzyl alcohol

There total 13 articles about (R)-α-cyclopropylbenzyl alcohol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.7%

cyclopropyl phenyl ketone (3481-02-5) → (R)-α-cyclopropylbenzyl alcohol (110548-55-5)

Guidance literature:

With (S,S)-RuCl₂(2,2'-bis(di-3,5-xylylphosphino)-1,1'-binaphthyl)(1,1-dianisyl-2-isopropyl-1,2-ethylenediamine); hydrogen; potassium carbonate; In isopropyl alcohol; at 28 - 30 ℃; for 14h; under 6080 Torr;

DOI:10.1021/ja983257u

Reference yield: 96.0%

→ (S)-α-cyclopropylbenzyl alcohol (110548-56-6) + (R)-α-cyclopropylbenzyl alcohol (110548-55-5)

Guidance literature:

With C₃₆H₂₈FeMnN₂O₃P⁽¹⁺⁾*Br^(1-); potassium carbonate; In ethanol; at 20 ℃; for 0.0833333h; Glovebox;

With hydrogen; In ethanol; at 50 ℃; for 16h; under 22502.3 Torr; Glovebox; Autoclave;

Reference yield: 35.0%

vinyl acetate (108-05-4,9003-20-7) + 1-phenyl-1-cyclopropylmethanol (1007-03-0) → (R)-α-cyclopropylbenzyl acetate + (S)-α-cyclopropylbenzyl alcohol (110548-56-6) + (R)-α-cyclopropylbenzyl alcohol (110548-55-5)

Guidance literature:

With Novozym 435, CAL-B; In carbon dioxide; at 20 ℃; for 48h; under 52505.3 Torr; enantioselective reaction; Resolution of racemate; Autoclave; Enzymatic reaction; liquid CO₂;

DOI:10.1016/j.tet.2015.11.052

upstream raw materials:

benzylcyclopropane

1-phenyl-1-cyclopropylmethanol

dicyclopropylzinc

benzaldehyde

Refernces

• 1、 Hu, Xile,Zhang, Zhikun. "Visible-Light-Driven Catalytic Deracemization of Secondary Alcohols". supporting information. p. 22833 - 22838. Retrieved 2021/09/09.
• 2、 -. "Tridentate nitrogen phosphine ligand containing arylamine NH as well as preparation method and application thereof". Paragraph 0095-0102; 0105-0109. . Retrieved 2021/06/26.