4-Amino-1-cyclopropylpiperidine

Base Information

• Chemical Name: 4-Amino-1-cyclopropylpiperidine
• CAS No.: 62813-02-9
• Molecular Formula: C8H16 N2
• Molecular Weight: 140.228
• Hs Code.: 2933399090
• Mol file: 62813-02-9.mol

Synonyms:(1-Cyclopropylpiperidin-4-yl)amine;4-Amino-1-cyclopropylpiperidine

Chemical Property of 4-Amino-1-cyclopropylpiperidine

Chemical Property:

• Vapor Pressure: 0.431mmHg at 25°C
• Boiling Point: 194.924oC at 760 mmHg
• PKA: 10.51±0.20(Predicted)
• Flash Point: 66.824oC
• PSA: 29.26000
• Density: 1.063g/cm3
• LogP: 1.21010

Purity/Quality:

98%Min ^*data from raw suppliers

1-cyclopropylpiperidin-4-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Amino-1-cyclopropylpiperidine

There total 5 articles about 4-Amino-1-cyclopropylpiperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

→ 1-Cyclopropyl-piperidin-4-ylamine (62813-02-9)

Guidance literature:

Reference yield: 64.0%

N-benzyl-1-cyclopropyl-piperidin-4-amine (1001345-77-2) → 1-Cyclopropyl-piperidin-4-ylamine (62813-02-9)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In methanol; at 30 ℃; for 16h; under 3750.38 Torr;

Reference yield:

1-cyclopropylpiperidin-4-one (62813-01-8) → 1-Cyclopropyl-piperidin-4-ylamine (62813-02-9)

Guidance literature:

With ammonia; hydrogen; In methanol; at 15 ℃; for 1h; under 775.743 Torr; Inert atmosphere;

upstream raw materials:

N-benzyl-1-cyclopropyl-piperidin-4-amine

1-cyclopropylpiperidin-4-one

methanol hydrochloride

tert-butyl N-(1-cyclopropyl-4-piperidyl)carbamate

Downstream raw materials:

tert-butyl N-(1-cyclopropyl-4-piperidyl)carbamate

4-(1-cyclopropylpiperidin-4-ylamino)-3-nitrobenzenesulfonamide

4-(9-cyclopentyl-7,7-difluoro-5-methyl-6-oxo-6,7,8,9-tetrahydro-5H-pyrimido[4,5-b][1,4]diazepin-2-ylamino)-N-(1-cyclopropyl-piperidin-4-yl)-3-methoxy-benzamide

Refernces

• 1、 -. "NOVEL COMPOUNDS". Page/Page column 107. . Retrieved 2008/06/13.
• 2、 -. "ALKYLCARBAMOYL NAPHTHALENYLOXY- OCTENOYLHYDROXYAMIDE DERIVATIVES HAVING INHIBITORY ACTIVITY AGAINST HISTONE DEACETYLASE AND PREPARATION THEREOF". Page/Page column 21. . Retrieved 2010/11/27.