TERT-BUTYL 5-BROMOPYRIDINE-2-CARBOXYLATE 98

Base Information

• Chemical Name: TERT-BUTYL 5-BROMOPYRIDINE-2-CARBOXYLATE 98
• CAS No.: 845306-08-3
• Molecular Formula: C10H12BrNO2
• Molecular Weight: 258.115
• Hs Code.: 2933399090
• Mol file: 845306-08-3.mol

Synonyms:5-Bromopyridine-2-carboxylicacid tert-butyl ester;tert-Butyl 5-bromopyridine-2-carboxylate;

Chemical Property of TERT-BUTYL 5-BROMOPYRIDINE-2-CARBOXYLATE 98

Chemical Property:

• Vapor Pressure: 0.00038mmHg at 25°C
• Melting Point: 92-94 °C
• Refractive Index: 1.531
• Boiling Point: 317.6 °C at 760 mmHg
• PKA: -0.52±0.10(Predicted)
• Flash Point: 145.9 °C
• PSA: 39.19000
• Density: 1.385 g/cm³
• LogP: 2.79940
• Storage Temp.: Keep Cold

Purity/Quality:

98% ^*data from raw suppliers

t-Butyl5-bromopicolinate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of TERT-BUTYL 5-BROMOPYRIDINE-2-CARBOXYLATE 98

There total 4 articles about TERT-BUTYL 5-BROMOPYRIDINE-2-CARBOXYLATE 98 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

methyl 5-bromopicolinate (29682-15-3) + tert-butyl alcohol (75-65-0) → tert-butyl 5-bromopyridine-2-carboxylate (845306-08-3)

Guidance literature:

tert-butyl alcohol; With n-butyllithium; In tetrahydrofuran; hexane; at 0 ℃; for 0.166667h;

methyl 5-bromopicolinate; In tetrahydrofuran; hexane; at 0 ℃;

DOI:10.1021/ol801035c

Reference yield: 73.0%

5-bromoisonicotinic acid (30766-11-1) + tert-butyl alcohol (75-65-0) → tert-butyl 5-bromopyridine-2-carboxylate (845306-08-3)

Guidance literature:

With pyridine; p-toluenesulfonyl chloride; at 20 - 40 ℃; for 2.16667h;

Reference yield:

5-bromoisonicotinic acid (30766-11-1) → tert-butyl 5-bromopyridine-2-carboxylate (845306-08-3)

Guidance literature:

With dmap; In tert-butyl alcohol;

upstream raw materials:

5-bromoisonicotinic acid

tert-butyl alcohol

methyl 5-bromopicolinate

N,N-dimethylformamide di-tert-butyl acetal

Downstream raw materials:

tert-butyl 5H-pyrido[3,2-b]indole-2-carboxylate

3-tert-butoxycarbonyl-β-carboline

tert-butyl 5-formylpicolinate

Refernces

• 1、 -. "ANDROGEN RECEPTOR MODULATING CARBOXAMIDES". Page/Page column. . Retrieved 2015/05/06.
• 2、 Martin, Thibaut,Verrier, Cecile,Hoarau, Christophe,Marsais, Francis. "Direct C-2 arylation of alkyl 4-thiazolecarboxylates: New insights in synthesis of heterocyclic core of thiopeptide antibiotics". supporting information; experimental part. p. 2909 - 2912. Retrieved 2009/05/30.