6-IODO-2-METHYL-1,3-BENZOTHIAZOLE 90

Base Information

• Chemical Name: 6-IODO-2-METHYL-1,3-BENZOTHIAZOLE 90
• CAS No.: 68867-20-9
• Molecular Formula: C8H6 I N S
• Molecular Weight: 275.113
• Hs Code.: 2934208090
• Mol file: 68867-20-9.mol

Synonyms:6-Iodo-2-methylbenzo[d]thiazole

Chemical Property of 6-IODO-2-METHYL-1,3-BENZOTHIAZOLE 90

Chemical Property:

• Vapor Pressure: 0.000495mmHg at 25°C
• Melting Point: 134oC
• Boiling Point: 323.4oC at 760 mmHg
• Flash Point: 149.4oC
• PSA: 41.13000
• Density: 1.902g/cm3
• LogP: 3.20930

Purity/Quality:

98%min ^*data from raw suppliers

6-Iodo-2-methyl-1,3-benzothiazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-IODO-2-METHYL-1,3-BENZOTHIAZOLE 90

There total 11 articles about 6-IODO-2-METHYL-1,3-BENZOTHIAZOLE 90 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

6-amino-2-methylbenzothiazole (2941-62-0) → 6-iodo-2-methyl-1,3-benzothiazole (68867-20-9)

Guidance literature:

6-amino-2-methylbenzothiazole; With hydrogenchloride; sodium nitrite; for 0.5h; cooling;

With potassium iodide; In water; at 40 ℃; for 0.166667h;

DOI:10.1002/hlca.200590084

Reference yield: 55.0%

N-(4-iodophenyl)thioacetamide (20980-01-2) → 6-iodo-2-methyl-1,3-benzothiazole (68867-20-9)

Guidance literature:

With sodium hydroxide; potassium hexacyanoferrate(III); In water; at 20 ℃; Cooling with ice;

DOI:10.1021/jo201411t

Reference yield: 50.0%

N-(2-iodo-4-iodophenyl)acetamide (861613-82-3) → 6-iodo-2-methyl-1,3-benzothiazole (68867-20-9)

Guidance literature:

N-(2-iodo-4-iodophenyl)acetamide; With copper(l) iodide; sodiumsulfide nonahydrate; In N,N-dimethyl-formamide; at 80 ℃; for 12h;

With hydrogenchloride; In water; N,N-dimethyl-formamide; at 80 ℃; for 12h;

DOI:10.1021/acs.jmedchem.5b00440

upstream raw materials:

N-(4-iodophenyl)thioacetamide

6-amino-2-methylbenzothiazole

2-Methylbenzothiazole

2-methyl-6-nitrobenzothiazole

Downstream raw materials:

6-[(4-diphenylaminophenyl)ethyn-1-yl]benzothiazole-2-carbaldehyde

2-{{6-[(4-diphenylaminophenyl)ethyn-1-yl]benzothiazol-2-yl}methylene}malononitrile

(E)-6-[4-(N,N-diphenylamino)phenylethenyl]-2-methylbenzothiazole

(E)-6-[4-(N,N-dimethylamino)phenylethenyl]-2-methylbenzothiazole

Refernces

• 1、 -. "RADIOACTIVE IODINE LABELED STYRYL SUBSTITUTED AROMATIC HETEROCYCLIC COMPOUND". . . Retrieved 2016/11/21.
• 2、 -. "Radioactive iodine labeled compound, and, radioactive pharmaceutical containing the same (by machine translation)". . . Retrieved 2018/10/10.