1-BOC-2-ETHYL-PIPERIDIN-4-ONE

Base Information

• Chemical Name: 1-BOC-2-ETHYL-PIPERIDIN-4-ONE
• CAS No.: 324769-07-5
• Molecular Formula: C12H21NO3
• Molecular Weight: 227.304
• Hs Code.: 2933399090
• Mol file: 324769-07-5.mol

Synonyms:1-(tert-Butoxycarbonyl)-2-ethyl-4-oxopiperidine;

Chemical Property of 1-BOC-2-ETHYL-PIPERIDIN-4-ONE

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.469
• Boiling Point: 315.397 °C at 760 mmHg
• PKA: -1.52±0.40(Predicted)
• Flash Point: 144.547 °C
• PSA: 46.61000
• Density: 1.039 g/cm³
• LogP: 2.30290
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%min ^*data from raw suppliers

1-Boc-2-ethyl-piperidin-4-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-BOC-2-ETHYL-PIPERIDIN-4-ONE

There total 1 articles about 1-BOC-2-ETHYL-PIPERIDIN-4-ONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ tert-butyl 2-ethyl-4-oxopiperidine-1-carboxylate (324769-07-5)

Guidance literature:

Reference yield: 95.0%

tert-butyl 2-ethyl-4-oxopiperidine-1-carboxylate (324769-07-5) + benzyltriphenylphosphonium bromide (1449-46-3) → C19H27NO2

Guidance literature:

benzyltriphenylphosphonium bromide; With potassium tert-butylate; In tetrahydrofuran; at 23 ℃; for 0.5h; Inert atmosphere;

tert-butyl 2-ethyl-4-oxopiperidine-1-carboxylate; In tetrahydrofuran; for 24h; Inert atmosphere;

DOI:10.1021/jacs.5b07201

Reference yield: 76.0%

tert-butyl 2-ethyl-4-oxopiperidine-1-carboxylate (324769-07-5) + 3,5-bis-trifluoromethylbenzylamine (85068-29-7) → 4-(3,5-bis-trifluoromethyl-benzylamino)-2-ethyl-piperidine-1-carboxylic acid tert-butyl ester (1003843-71-7)

Guidance literature:

tert-butyl 2-ethyl-4-oxopiperidine-1-carboxylate; 3,5-bis-trifluoromethylbenzylamine; With sodium tetrahydroborate; titanium(IV) isopropylate; In methanol; 1,2-dichloro-ethane; at 20 ℃; for 6h;

With water; ammonium chloride; In methanol; 1,2-dichloro-ethane;

Downstream raw materials:

4-(3,5-bis-trifluoromethyl-benzylamino)-2-ethyl-piperidine-1-carboxylic acid tert-butyl ester

2-methylpropan-2-yl 6-ethyl-4-[4-nitro-3-(propan-2-yloxy)phenyl]-3,6-dihydropyridine-1(2H)-carboxylate

2-methylpropan-2-yl 4-[4-amino-3-(propan-2-yloxy)phenyl]-2-ethylpiperidine-1-carboxylate

Refernces

• 1、 -. "SEROTONERGIC BENZOFURANS". Page/Page column 30. . Retrieved 2010/02/04.