A-83-01

Base Information

• Chemical Name: A-83-01
• CAS No.: 909910-43-6
• Molecular Formula: C25H19N5S
• Molecular Weight: 421.525
• Mol file: 909910-43-6.mol

Synonyms:A 83-01;

Chemical Property of A-83-01

Chemical Property:

• Vapor Pressure: 6.75E-14mmHg at 25°C
• Melting Point: 111℃
• Refractive Index: 1.706
• Boiling Point: 590 °C at 760 mmHg
• PKA: 8.77±0.70(Predicted)
• Flash Point: 310.6 °C
• PSA: 87.72000
• Density: 1.27g/cm³
• LogP: 5.78680
• Storage Temp.: Store at -20°C
• Solubility.: DMSO: soluble5mg/mL, clear (warmed)

Purity/Quality:

98%,99%, ^*data from raw suppliers

A 83-01 ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Description: A 83-01 (909910-43-6) is a potent and selective ALK4, 5 and 7 inhibitor.1,2?IC50 = 45, 12 and 7.5 nM respectively. Prevents phosphorylation of Smad2/3 and growth inhibition induced by TGFβ.2?Inhibits differentiation of rat induced pluripotent stem cells and increases clonal expansion efficiency.3?Together with AMI-5, A83-01 enabled Oct4-induced reprogramming of mouse embryonic fibroblasts.4?Cell permeable. Active in vivo.
• Uses: A 83-01 is a selective inhibitor of TGF-β type I receptor. A 83-01 treatment increases tumor permeability. A 83-01 has been used as an inhibitor of transforming growth factor β kinase type 1 receptor.