(R)-(+)-2-Butylbutanedioic acid 4-tert-butyl ester

Base Information Edit

Chemical Name:(R)-(+)-2-Butylbutanedioic acid 4-tert-butyl ester
CAS No.:200866-61-1
Molecular Formula:C12H22O4
Molecular Weight:230.304
Hs Code.:
Mol file:200866-61-1.mol

Synonyms:Butanedioicacid, butyl-, 4-(1,1-dimethylethyl) ester, (2R)- (9CI);Butanedioic acid,butyl-, 4-(1,1-dimethylethyl) ester, (R)-;

Suppliers and Price of (R)-(+)-2-Butylbutanedioic acid 4-tert-butyl ester

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 7 raw suppliers

Chemical Property of (R)-(+)-2-Butylbutanedioic acid 4-tert-butyl ester Edit

Chemical Property:

Vapor Pressure:0mmHg at 25°C
Refractive Index:1.453
Boiling Point:330.317 °C at 760 mmHg
PKA:4.50±0.23(Predicted)
Flash Point:116.288 °C
PSA：63.60000
Density:1.023 g/cm³
LogP:2.60920

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of (R)-(+)-2-Butylbutanedioic acid 4-tert-butyl ester

There total 6 articles about (R)-(+)-2-Butylbutanedioic acid 4-tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 200866-59-7
tert-butyl (R)-3-((S)-4-benzyl-2-oxooxazolidine-3-carbonyl)heptanoate

: 200866-61-1
(R)-(+)-2-butylbutanedioic acid 4-tert-butyl monoester

Guidance literature:: tert-butyl (R)-3-((S)-4-benzyl-2-oxooxazolidine-3-carbonyl)heptanoate; With dihydrogen peroxide; In tetrahydrofuran; water; at 0 - 25 ℃; for 4.25h;

With lithium hydroxide; In tetrahydrofuran; water; for 0.5h;
DOI:10.1021/acs.jmedchem.0c00079

Reference yield:

: 143965-32-6
(4S)-3-hexanoyl-4-(phenylmethyl)-1,3-oxazolidin-2-one

: 200866-61-1
(R)-(+)-2-butylbutanedioic acid 4-tert-butyl monoester

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) lithium hexamethyldisilazide / 1.) THF, -78 deg C, 1 h, 2.) THF, a) -78 deg C, 1 h, b) -40 deg C, 1 h

2: 76 percent / aq. H₂O₂, LiOH / tetrahydrofuran / 3 h / 0 °C

With lithium hydroxide; dihydrogen peroxide; lithium hexamethyldisilazane; In tetrahydrofuran;
DOI:10.1021/jm970494j

Reference yield:

: 142-61-0
Hexanoyl chloride

: 200866-61-1
(R)-(+)-2-butylbutanedioic acid 4-tert-butyl monoester

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) n-BuLi / 1.) THF, - 78 deg C, 1 h, 2.) THF, a) -78 deg C, 1 h, b) RT, 1 h

2: 1.) lithium hexamethyldisilazide / 1.) THF, -78 deg C, 1 h, 2.) THF, a) -78 deg C, 1 h, b) -40 deg C, 1 h

3: 76 percent / aq. H₂O₂, LiOH / tetrahydrofuran / 3 h / 0 °C

With lithium hydroxide; n-butyllithium; dihydrogen peroxide; lithium hexamethyldisilazane; In tetrahydrofuran;
DOI:10.1021/jm970494j