Technology Process of Benzoic acid 2-trimethylsilanyloxy-pyrimidin-4-ylmethyl ester
There total 6 articles about Benzoic acid 2-trimethylsilanyloxy-pyrimidin-4-ylmethyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 98 percent / KOH, H2 / 5percent Pd/BaSO4 / methanol / 1810.02 Torr
2: 68 percent / N,N-dimethylchloromethyleniminium chloride, NaBH4 / CH2Cl2; tetrahydrofuran; acetonitrile; dimethylformamide / 3 h / -78 - -20 °C
3: 71 percent / methanol / 12 h / Heating
4: 98 percent / 4-(dimethylamino)pyridine, triethylamine / CH2Cl2 / 12 h / Ambient temperature
5: iodotrimethylsilane / acetonitrile / 70 - 75 °C
6: acetonitrile / 1 h / Heating
With
dmap; potassium hydroxide; sodium tetrahydroborate; trimethylsilyl iodide; N,N-dimethylchloromethyleniminium chloride; hydrogen; triethylamine;
Pd-BaSO4;
In
tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm00158a009
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 68 percent / N,N-dimethylchloromethyleniminium chloride, NaBH4 / CH2Cl2; tetrahydrofuran; acetonitrile; dimethylformamide / 3 h / -78 - -20 °C
2: 71 percent / methanol / 12 h / Heating
3: 98 percent / 4-(dimethylamino)pyridine, triethylamine / CH2Cl2 / 12 h / Ambient temperature
4: iodotrimethylsilane / acetonitrile / 70 - 75 °C
5: acetonitrile / 1 h / Heating
With
dmap; sodium tetrahydroborate; trimethylsilyl iodide; N,N-dimethylchloromethyleniminium chloride; triethylamine;
In
tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm00158a009
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 71 percent / methanol / 12 h / Heating
2: 98 percent / 4-(dimethylamino)pyridine, triethylamine / CH2Cl2 / 12 h / Ambient temperature
3: iodotrimethylsilane / acetonitrile / 70 - 75 °C
4: acetonitrile / 1 h / Heating
With
dmap; trimethylsilyl iodide; triethylamine;
In
methanol; dichloromethane; acetonitrile;
DOI:10.1021/jm00158a009