2,7-NAPHTHYRIDINE, 1-CHLORO-

Base Information

• Chemical Name: 2,7-NAPHTHYRIDINE, 1-CHLORO-
• CAS No.: 69042-30-4
• Molecular Formula: C8H5ClN2
• Molecular Weight: 164.594
• Hs Code.: 2933990090
• Mol file: 69042-30-4.mol

Synonyms:Copyrine,1-chloro- (6CI);1-Chloro-2,7-naphthyridine;

Chemical Property of 2,7-NAPHTHYRIDINE, 1-CHLORO-

Chemical Property:

• Boiling Point: 326.4 °C at 760 mmHg
• PKA: 2.52±0.30(Predicted)
• Flash Point: 181.1 °C
• PSA: 25.78000
• Density: 1.349 g/cm³
• LogP: 2.28320
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

1-Chloro-2,7-naphthyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,7-NAPHTHYRIDINE, 1-CHLORO-

There total 10 articles about 2,7-NAPHTHYRIDINE, 1-CHLORO- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2,7-naphthyridinyl-1(2H)-one (67988-50-5) → 1-chloro-[2,7]naphthyridine (69042-30-4)

Guidance literature:

With trichlorophosphate; at 120 ℃; for 30h; sealed vessel;

DOI:10.1055/s-0030-1259060

Reference yield: 85.5%

1-hydroxy-[2,7]-naphthyridine hydrochloride salt (369648-60-2) → 1-chloro-[2,7]naphthyridine (69042-30-4)

Guidance literature:

With trichlorophosphate; at 110 ℃; for 24h;

Reference yield: 68.0%

sodium carbonate (497-19-8) + 1-hydroxy-2,7-naphthyridine (67988-50-5) → 1-chloro-[2,7]naphthyridine (69042-30-4)

Guidance literature:

With trichlorophosphate;

upstream raw materials:

2,7-naphthyridinyl-1(2H)-one

4-methylnicotinic acid

3,4-dihydro-1H-pyrano[3,4-c]pyridin-1-one

4-(2-hydroxy-ethyl)-nicotinic acid amide

Downstream raw materials:

[2,7]naphthyridine

ethyl-(2S)-2-amino-3-[4-([2,7]naphthyridin-1-ylamino)phenyl]propanoate

ethyl-(2S)-3-[4-([2,7]naphthyridin-1-ylamino)phenyl]-2-[(t-butoxycarbonyl)amino]propanoate

UC⁽⁹³³⁾B₁₁₉₄

Refernces

• 1、 Andrew, Trisha L.,Vanveller, Brett,Swager, Timothy M.. "The synthesis of azaperylene-9,10-dicarboximides". supporting information; experimental part. p. 3045 - 3048. Retrieved 2011/02/25.
• 2、 -. "PHENYLALANINE ENAMIDE DERIVATIVES". Page 15-16. . Retrieved 2008/06/13.