4-Chloro-5-methylpyrimidine

Base Information

• Chemical Name: 4-Chloro-5-methylpyrimidine
• CAS No.: 51957-32-5
• Molecular Formula: C5H5ClN2
• Molecular Weight: 128.561
• Hs Code.: 2933599090
• Mol file: 51957-32-5.mol

Synonyms:4-CHLORO-5-METHYLPYRIMIDINE;Pyrimidine, 4-chloro-5-methyl- (6CI,9CI)

Chemical Property of 4-Chloro-5-methylpyrimidine

Chemical Property:

• Boiling Point: 195.2 °C at 760 mmHg
• PKA: 0.40±0.16(Predicted)
• Flash Point: 89.6 °C
• PSA: 25.78000
• Density: 1.234 g/cm³
• LogP: 1.43840
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

4-Chloro-5-methylpyrimidine 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Chloro-5-methylpyrimidine

There total 1 articles about 4-Chloro-5-methylpyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-methyl-4(3H)-pyrimidinone (17758-52-0) → 4-chloro-5-methyl-pyrimidine (51957-32-5)

Guidance literature:

With trichlorophosphate;

Reference yield: 27.8%

4-chloro-5-methyl-pyrimidine (51957-32-5) + 2',5-dichloro-2-iodobenzophenone (76049-50-8) → 2-chloro-9H-fluoren-9-one (3096-47-7) + 5,5'-Dimethyl-4,4'-bipyrimidinyl (87999-62-0) + 2',5-Dichloro-2-(5-methyl-4-pyrimidinyl)benzophenone (87999-60-8) + 2,2'-Bis(o-chlorobenzoyl)-4,4'-dichlorobiphenyl (87999-61-9)

Guidance literature:

With bis(1,5-cyclooctadiene)nickel ⁽⁰⁾; In N,N-dimethyl-formamide; at 40 ℃; for 48h;

DOI:10.1021/jo00176a015

Reference yield: 7.0%

4-tert-Butylaniline (769-92-6) + 4-chloro-5-methyl-pyrimidine (51957-32-5) → C15H19N3

Guidance literature:

With palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate; In toluene; for 12h; Reflux;

upstream raw materials:

5-methyl-4(3H)-pyrimidinone

Downstream raw materials:

5-methylpyrimidine

(5-methyl-pyrimidin-4-yl)-hydrazine

2-chloro-9H-fluoren-9-one

5,5'-Dimethyl-4,4'-bipyrimidinyl