2-(2-(2-Aminoethoxy)ethoxy)acetic acid

Base Information

• Chemical Name: 2-(2-(2-Aminoethoxy)ethoxy)acetic acid
• CAS No.: 134978-97-5
• Molecular Formula: C6H13NO4
• Molecular Weight: 163.174
• Hs Code.: 2922509090
• Mol file: 134978-97-5.mol

Synonyms:Acetic acid,[2-(2-aminoethoxy)ethoxy]- (9CI);8-Amino-3,6-dioxaoctanoic acid;NSC 626945;[2-(2-Aminoethoxy)ethoxy]acetic acid;

Chemical Property of 2-(2-(2-Aminoethoxy)ethoxy)acetic acid

Chemical Property:

• Vapor Pressure: 5.23E-05mmHg at 25°C
• Melting Point: 124.0 to 128.0 °C
• Refractive Index: 1.466
• Boiling Point: 323.8 °C at 760 mmHg
• PKA: 3.37±0.10(Predicted)
• Flash Point: 149.6 °C
• PSA: 81.78000
• Density: 1.177 g/cm³
• LogP: -0.23680
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• Solubility.: DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

98%,99%, ^*data from raw suppliers

[2-(2-Aminoethoxy)ethoxy]aceticAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Description: Amino-PEG2-CH2CO2H is a PEG compound containing an amino group with a terminal carboxylic acid. The amine group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.
• Uses: [2-(2-Aminoethoxy)ethoxy]acetic Acid is used in the development of chemically modified peptide nucleic acid (PNA) as a probe for qualitative and quantitative detection of DNA. It is also used in the preparation and studies of the biological activities of kappa agonist CovX-bodies.

Technology Process of 2-(2-(2-Aminoethoxy)ethoxy)acetic acid

There total 13 articles about 2-(2-(2-Aminoethoxy)ethoxy)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

N-(2-(2-(2-azidoethoxy)ethoxy))acetic acid (882518-90-3) → [2-(N-2-amino ethoxy)ethoxy] acetic acid (134978-97-5,139729-28-5)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In ethanol; at 4 - 20 ℃;

DOI:10.1039/b807263a

Reference yield: 92.0%

C6H11NO3 → [2-(N-2-amino ethoxy)ethoxy] acetic acid (134978-97-5,139729-28-5)

Guidance literature:

With hydrogenchloride; In water; for 2h; Reflux;

Reference yield:

[2-(2-dibenzylaminoethoxy)ethoxy]acetic acid (166108-70-9) → [2-(N-2-amino ethoxy)ethoxy] acetic acid (134978-97-5,139729-28-5)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; at 45 ℃; for 20h; under 760 Torr;

DOI:10.1021/ol0502578

upstream raw materials:

[2-(2-dibenzylaminoethoxy)ethoxy]acetic acid

8-(9-fluorenylmethyloxycarbonyl-amino)-3,6-dioxaoctanoic acid

N-(2-(2-(2-azidoethoxy)ethoxy))acetic acid

N-(tert-butyloxycarbonyl)-8-amino-3,6-dioxaoctanoic acid

Downstream raw materials:

N-(tert-butyloxycarbonyl)-8-amino-3,6-dioxaoctanoic acid

8-(9-fluorenylmethyloxycarbonyl-amino)-3,6-dioxaoctanoic acid

2,2-dimethyl-4,13-dioxo-3,8,11,17,20-pentaoxa-5,14-diazadocosan-22-oic acid

Refernces

• 1、 -. "Preparation method of AEEA". Paragraph 0067-0069. . Retrieved 2021/10/27.
• 2、 Yao, Hong,Wei, Guoxiang,Liu, Yanpeng,Yao, Hequan,Zhu, Zheying,Ye, Wencai,Wu, Xiaoming,Xu, Jinyi,Xu, Shengtao. "Synthesis, Biological Evaluation of Fluorescent 23-Hydroxybetulinic Acid Probes, and Their Cellular Localization Studies". . p. 1030 - 1034. Retrieved 2018/10/15.