Methyl 3-[4-(aminomethyl)phenyl]propionate

Base Information

• Chemical Name: Methyl 3-[4-(aminomethyl)phenyl]propionate
• CAS No.: 100511-78-2
• Molecular Formula: C11H15NO2
• Molecular Weight: 193.246
• Hs Code.: 2922499990
• Mol file: 100511-78-2.mol

Synonyms:3-[4-(Aminomethyl)phenyl]propionicacid methyl ester;4-(2-Methoxycarbonylethyl)benzylamine;NSC 46327;

Chemical Property of Methyl 3-[4-(aminomethyl)phenyl]propionate

Chemical Property:

• Vapor Pressure: 0.0012mmHg at 25°C
• Refractive Index: 1.53
• Boiling Point: 299.4 °C at 760 mmHg
• PKA: 9.13±0.10(Predicted)
• Flash Point: 155 °C
• PSA: 52.32000
• Density: 1.081 g/cm³
• LogP: 1.95120

Purity/Quality:

99% ^*data from raw suppliers

Methyl 3-[4-(Aminomethyl)phenyl]propanoate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl 3-[4-(aminomethyl)phenyl]propionate

There total 10 articles about Methyl 3-[4-(aminomethyl)phenyl]propionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.54%

methyl 3-(4-cyanophenyl)propenoate (67472-79-1) → methyl 3-(4-aminomethylphenyl)propionate (100511-78-2)

Guidance literature:

aluminum nickel; In methanol; ammonia;

Reference yield: 86.0%

(E)-3-[4-(aminomethyl)phenyl]acrylate methyl ester → methyl 3-(4-aminomethylphenyl)propionate (100511-78-2)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; for 12h; under 2585.81 Torr;

Reference yield: 24.7%

3-(p-Cyanophenyl)-propansaeuremethylester (75567-85-0) → methyl 3-(4-aminomethylphenyl)propionate (100511-78-2)

Guidance literature:

With ammonium hydroxide; hydrogen; In methanol; at 20 ℃; for 3h;

upstream raw materials:

methyl 3-(4-cyanophenyl)propenoate

4-Bromobenzylamine

methyl 4-[[[(1,1-dimethylethoxy)carbonyl]amino]methyl]benzenepropanoate

tert-butyl N-(4-bromobenzyl)carbamate

Downstream raw materials:

β-[4-(5-chloro-2-methoxybenzamidomethyl)-phenyl]-propionic acid

3-[4-[(tert.Butyloxycarbonylamino)methyl]phenyl]propionic acid

N-[4-(2-methoxycarbonyl-ethyl)-phenylmethyl]-4-(4'-trifluoromethyl-biphenyl-2-carbonylamino)-1-methyl-pyrrole-2-carboxylic acid amide

Refernces

• 1、 -. "BIARYL UREA DERIVATIVE OR SALT THEREOF, AND MANUFACTURING AND APPLICATION OF SAME". . . Retrieved 2019/05/10.
• 2、 -. "ALKYNYL ARYL CARBOXAMIDES". Page/Page column 54-55. . Retrieved 2008/06/13.