(R)-3-AMINO-5,5-DIMETHYLHEXANOIC ACID

Base Information

• Chemical Name: (R)-3-AMINO-5,5-DIMETHYLHEXANOIC ACID
• CAS No.: 147228-35-1
• Molecular Formula: C₈H₁₇NO₂
• Molecular Weight: 159.228
• Mol file: 147228-35-1.mol

Synonyms:(R)-3-Amino-5,5-dimethylhexanoic acid;

Chemical Property of (R)-3-AMINO-5,5-DIMETHYLHEXANOIC ACID

Chemical Property:

• Refractive Index: 1.466
• Boiling Point: 259.2 °C at 760 mmHg
• PKA: 3.81±0.10(Predicted)
• Flash Point: 110.6 °C
• PSA: 63.32000
• Density: 0.999 g/cm³
• LogP: 1.92490
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%min ^*data from raw suppliers

(R)-3-Amino-5,5-dimethylhexanoicacidhydrochloride 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (R)-3-AMINO-5,5-DIMETHYLHEXANOIC ACID

There total 2 articles about (R)-3-AMINO-5,5-DIMETHYLHEXANOIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(3R)-ethyl 5,5-dimethyl-3-(tosylamino)hexanoate (147228-25-9) → (3R)-3-amino-5,5-dimethylhexanoic acid (147228-35-1,218608-81-2,727971-57-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 94 percent / K₂CO₃ / methanol; H₂O / 24 h / Ambient temperature

2: 1.) 47percent aq. HBr, 2.) methyloxirane / 1.) phenol, reflux, 4 h, 2.) EtOH, reflux, 2 h

With hydrogen bromide; potassium carbonate; methyloxirane; In methanol; water;

DOI:10.1002/hlca.19960790426

Reference yield:

(3R)-5,5-dimethyl-3-(tosylamino)hexanoic acid (147228-31-7) → (3R)-3-amino-5,5-dimethylhexanoic acid (147228-35-1,218608-81-2,727971-57-5)

Guidance literature:

With hydrogen bromide; methyloxirane; phenol; Yield given. Multistep reaction; 1) reflux, 4 h;

DOI:10.1016/S0040-4039(00)77503-4

upstream raw materials:

(3R)-5,5-dimethyl-3-(tosylamino)hexanoic acid

(3R)-ethyl 5,5-dimethyl-3-(tosylamino)hexanoate

Refernces

• 1、 Jefford,Wang. "An enantiospecific synthesis of β-amino acids". . p. 1111 - 1114. Retrieved 2007/10/02.