(R)-Piperidine-2-carboxylic acid methyl ester hydrochloride

Base Information

• Chemical Name: (R)-Piperidine-2-carboxylic acid methyl ester hydrochloride
• CAS No.: 18650-38-9
• Molecular Formula: C7H13 N O2 . Cl H
• Molecular Weight: 179.647
• Hs Code.: 2933399090
• Mol file: 18650-38-9.mol

Synonyms:2-Piperidinecarboxylicacid, methyl ester, hydrochloride, (2R)- (9CI); 2-Piperidinecarboxylic acid,methyl ester, hydrochloride, (R)-; Pipecolic acid, methyl ester, hydrochloride,(R)- (8CI); (R)-2-Piperidinecarboxylic acid methyl ester hydrochloride;(R)-Piperidine-2-carboxylic acid methyl ester hydrochloride

Chemical Property of (R)-Piperidine-2-carboxylic acid methyl ester hydrochloride

Chemical Property:

• PSA: 38.33000
• LogP: 1.43230
• Storage Temp.: 2-8°C
• Solubility.: DMSO (Slightly, Sonicated), Methanol (Slightly)

Purity/Quality:

98% ^*data from raw suppliers

(R)-Piperidine-2-CarboxylicAcidMethylEsterHydrochloride ^*data from reagent suppliers

Safty Information:

• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Uses: (R)-Piperidine-2-carboxylic Acid Methyl Ester Hydrochloride is used in preparation and application of aromatic compound having immunoregulatory function.

Technology Process of (R)-Piperidine-2-carboxylic acid methyl ester hydrochloride

There total 4 articles about (R)-Piperidine-2-carboxylic acid methyl ester hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methanol (67-56-1) + (R)-(+)-pipecolic acid (1723-00-8,83680-83-5) → (R)-piperidine-2-carboxylic acid methyl ester hydrochloride (18650-38-9)

Guidance literature:

With thionyl chloride; for 8h; Reflux;

DOI:10.1002/cmdc.201300022

Reference yield:

Piperidine-1,2-dicarboxylic acid 2-methyl ester 1-phenyl ester → (S)-methyl pipecolinate hydrochloride (18650-39-0) + (R)-piperidine-2-carboxylic acid methyl ester hydrochloride (18650-38-9)

Guidance literature:

With hydrogenchloride; hydrogen; platinum(IV) oxide; In methanol; Yield given. Yields of byproduct given. Title compound not separated from byproducts;

DOI:10.1021/jo00114a006

Reference yield:

2-Picolinic acid (98-98-6) → (R)-piperidine-2-carboxylic acid methyl ester hydrochloride (18650-38-9)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂

2: HCl

With hydrogenchloride; hydrogen;

DOI:10.1016/0040-4039(90)80223-9

upstream raw materials:

methanol

(R)-(+)-pipecolic acid

2-Picolinic acid

N-BOC-D-pipecolic acid

Downstream raw materials:

C₁₂H₁₉NO₃

C₁₃H₂₁NO₃

C₁₈H₂₁N₃O₂

C₂₀H₂₅N₃O₂

Refernces

• 1、 Xia, Guangxin,Liu, Lin,Liu, Haiyan,Yu, Jianxin,Xu, Zhenmin,Chen, Qian,Ma, Chen,Li, Ping,Xiong, Bing,Liu, Xuejun,Shen, Jingkang. "Design and Synthesis of (R)-1-Arylsulfonylpiperidine-2-carboxamides as 11β-Hydroxysteroid Dehydrogenase Type1 Inhibitors". supporting information. p. 577 - 581. Retrieved 2013/08/22.
• 2、 Kirira, Peter G.,Kuriyama, Masami,Onomura, Osamu. "Electrochemical deallylation of α-allyl cyclic amines and synthesis of optically active quaternary cyclic amino acids". experimental part. p. 3970 - 3982. Retrieved 2010/07/04.