Tetrahydro-3-furancarboxylic acid hydrazide

Base Information

• Chemical Name: Tetrahydro-3-furancarboxylic acid hydrazide
• CAS No.: 59293-32-2
• Molecular Formula: C5H10 N2 O2
• Molecular Weight: 130.15
• Hs Code.: 2932190090
• Mol file: 59293-32-2.mol

Synonyms:3-Furoicacid, tetrahydro-, hydrazide (6CI); 3-Tetrahydrofurancarboxylic acid hydrazide

Chemical Property of Tetrahydro-3-furancarboxylic acid hydrazide

Chemical Property:

• Boiling Point: 336.7±31.0 °C(Predicted)
• PKA: 13.20±0.20(Predicted)
• PSA: 64.35000
• Density: 1.216±0.06 g/cm3(Predicted)
• LogP: 0.10400
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%min ^*data from raw suppliers

Tetrahydrofuran-3-carbohydrazide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Tetrahydro-3-furancarboxylic acid hydrazide

There total 4 articles about Tetrahydro-3-furancarboxylic acid hydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-tetrahydrofuroic acid (89364-31-8) → tetrahydrofuran-3-carboxylic acid hydrazide (59293-32-2)

Guidance literature:

3-tetrahydrofuroic acid; With triethylamine; isobutyl chloroformate; In tetrahydrofuran; at 0 ℃; for 1h;

With hydrazine; In tetrahydrofuran; at 20 ℃; for 1h;

Reference yield:

ethyl 1-methyl-5-oxopyrrolidine-2-carboxylate (108645-70-1,177314-35-1) → tetrahydrofuran-3-carboxylic acid hydrazide (59293-32-2)

Guidance literature:

With hydrazine hydrate; In ethanol; at 23 ℃; for 17.33h; Cooling with ice;

Reference yield:

→ tetrahydrofuran-3-carboxylic acid hydrazide (59293-32-2)

Guidance literature:

With ethanol; hydrazine hydrate;

DOI:10.1002/hlca.19570400404

upstream raw materials:

3-tetrahydrofuroic acid

ethyl 1-methyl-5-oxopyrrolidine-2-carboxylate

Refernces

• 1、 -. "HETEROCYCLIC TRIAZOLE COMPOUNDS AS AGONISTS OF THE APJ RECEPTOR". Paragraph 1013; 1014. . Retrieved 2017/12/01.