5-(Aminosulfonyl)-3-chloro-1-methyl-1H-pyrazole-4-carboxylic acid ethyl ester

Base Information

• Chemical Name: 5-(Aminosulfonyl)-3-chloro-1-methyl-1H-pyrazole-4-carboxylic acid ethyl ester
• CAS No.: 100784-26-7
• Molecular Formula: C₇H₁₀ClN₃O₄S
• Molecular Weight: 267.693
• Hs Code.: 2935009090
• Mol file: 100784-26-7.mol

Synonyms:5-(Aminosulfonyl)-3-chloro-1-methyl-1H-pyrazole-4-carboxylic acid ethyl ester;Ethyl 3-chloro-5-aminosulfonyl-1-methylpyrazole-4-carboxylate;Ethyl 3-chloro-1-Methyl-5-sulfaMoyl-1H-pyrazole-4-carboxylate

Chemical Property of 5-(Aminosulfonyl)-3-chloro-1-methyl-1H-pyrazole-4-carboxylic acid ethyl ester

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 121-123 oC
• Refractive Index: 1.633
• Boiling Point: 475.376 °C at 760 mmHg
• PKA: 9.25±0.60(Predicted)
• Flash Point: 241.299 °C
• PSA: 112.66000
• Density: 1.665 g/cm³
• LogP: 1.67870

Purity/Quality:

98%min ^*data from raw suppliers

Ethyl3-chloro-1-methyl-5-sulfamoyl-1H-pyrazole-4-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-(Aminosulfonyl)-3-chloro-1-methyl-1H-pyrazole-4-carboxylic acid ethyl ester

There total 3 articles about 5-(Aminosulfonyl)-3-chloro-1-methyl-1H-pyrazole-4-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-chloro-succinimide (128-09-6) + ethyl 1-methyl-3-chloro-pyrazole-4-carboxylate (118197-42-5) + 3-chloro-4-ethoxycarbonyl-1-methylpyrazole-5-sulfonyl chloride (109056-73-7) → ethyl 3-chloro-1-methyl-5-sulfamoylpyrazole-4-carboxylate (100784-26-7)

Guidance literature:

With ammonium hydroxide; lithium diisopropyl amide; In ice-water; diethyl ether; dichloromethane;

Reference yield:

3-chloro-4-ethoxycarbonyl-1-methylpyrazole-5-sulfonyl chloride (109056-73-7) → ethyl 3-chloro-1-methyl-5-sulfamoylpyrazole-4-carboxylate (100784-26-7)

Guidance literature:

With ammonium hydroxide; In tetrahydrofuran; for 1h; Yield given; Ambient temperature;

DOI:10.1002/jhet.5570280808

Reference yield:

ethyl 1-methyl-3-chloro-pyrazole-4-carboxylate (118197-42-5) → ethyl 3-chloro-1-methyl-5-sulfamoylpyrazole-4-carboxylate (100784-26-7)

Guidance literature:

Multi-step reaction with 2 steps

2: 28percent aq. NH₄OH / tetrahydrofuran / 1 h / Ambient temperature

With ammonium hydroxide; In tetrahydrofuran;

DOI:10.1002/jhet.5570280808

upstream raw materials:

3-chloro-4-ethoxycarbonyl-1-methylpyrazole-5-sulfonyl chloride

ethyl 1-methyl-3-chloro-pyrazole-4-carboxylate

N-chloro-succinimide

Refernces

• 1、 -. "Pyrazolesulfonylurea useful for controlling the growth of undesired vegetation". . . Retrieved 2008/06/13.