Ethyl 6-bromobenzo[d]isothiazole-3-carboxylate

Base Information

• Chemical Name: Ethyl 6-bromobenzo[d]isothiazole-3-carboxylate
• CAS No.: 858671-74-6
• Molecular Formula: C10H8BrNO2S
• Molecular Weight: 286.14
• Hs Code.: 2934999090
• Mol file: 858671-74-6.mol

Synonyms:Ethyl 6-bromobenzo[d]isothiazole-3-carboxylate;

Chemical Property of Ethyl 6-bromobenzo[d]isothiazole-3-carboxylate

Chemical Property:

• Refractive Index: 1.652
• Boiling Point: 323.3 °C at 760 mmHg
• Flash Point: 149.3 °C
• PSA: 67.43000
• Density: 1.618 g/cm³
• LogP: 3.23550
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

Ethyl 6-bromo-1,2-benzothiazole-3-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Ethyl 6-bromobenzo[d]isothiazole-3-carboxylate

There total 1 articles about Ethyl 6-bromobenzo[d]isothiazole-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-bromo-benzo[d]isothiazole-3-carboxylic acid (677304-75-5) + ethanol (64-17-5) → ethyl 6-bromobenzo[d]isothiazole-3-carboxylate (858671-74-6)

Guidance literature:

With sulfuric acid;

Reference yield: 46.0%

ethyl 6-bromobenzo[d]isothiazole-3-carboxylate (858671-74-6) + 1-[(4-methoxyphenyl)methyl]-1H-pyrazolo[4,3-b]pyridin-3-amine → ethyl 6-((1-(4-methoxybenzyl)-1H-pyrazolo[4,3-b]pyridin-3-yl)amino)benzo[d]isothiazole-3-carboxylate

Guidance literature:

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; at 140 ℃; for 1h; Microwave irradiation;

DOI:10.1021/acs.jmedchem.8b00994

Reference yield:

ethyl 6-bromobenzo[d]isothiazole-3-carboxylate (858671-74-6) + 1-(4-methoxybenzyl)-1H-pyrazolo[3,4-b]pyrazine-3-amine (1432112-13-4) → C23H20N6O3S

Guidance literature:

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; at 140 ℃; for 1h; Microwave irradiation;

DOI:10.1021/acs.jmedchem.8b00994

upstream raw materials:

6-bromo-benzo[d]isothiazole-3-carboxylic acid

ethanol

Refernces

• 1、 -. "1 H-INDAZOLES, BENZOTHIAZOLES, 1,2-BENZOISOXAZOLES, 1,2-BENZOISOTHIAZOLES, AND CHROMONES AND PREPARATION AND USES THEREOF". Page/Page column 69. . Retrieved 2010/11/27.