Technology Process of tert-Butyl 4-(1H-indazol-3-yl)piperazine-1-carboxylate
There total 6 articles about tert-Butyl 4-(1H-indazol-3-yl)piperazine-1-carboxylate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
sodium hydroxide; water;
In
methanol;
at 90 ℃;
for 4h;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: toluene / 18 h / 75 °C
2.1: thionyl chloride / toluene / 60 - 75 °C
3.1: 1-methyl-pyrrolidin-2-one / 0.67 h / 20 °C
3.2: 3 h / 40 °C
4.1: copper; potassium carbonate / N,N-dimethyl-formamide / 1 h / Reflux
5.1: sodium hydroxide / methanol / 6 h / Reflux
With
thionyl chloride; copper; potassium carbonate; sodium hydroxide;
In
1-methyl-pyrrolidin-2-one; methanol; N,N-dimethyl-formamide; toluene;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: thionyl chloride / toluene / 18 h / Reflux
2.1: toluene / 18 h / 75 °C
3.1: thionyl chloride / toluene / 60 - 75 °C
4.1: 1-methyl-pyrrolidin-2-one / 0.67 h / 20 °C
4.2: 3 h / 40 °C
5.1: copper; potassium carbonate / N,N-dimethyl-formamide / 1 h / Reflux
6.1: sodium hydroxide / methanol / 6 h / Reflux
With
thionyl chloride; copper; potassium carbonate; sodium hydroxide;
In
1-methyl-pyrrolidin-2-one; methanol; N,N-dimethyl-formamide; toluene;