3-Nitro-7-azaindole

Base Information

• Chemical Name: 3-Nitro-7-azaindole
• CAS No.: 23709-47-9
• Molecular Formula: C7H5 N3 O2
• Molecular Weight: 163.136
• Hs Code.: 29339900
• Mol file: 23709-47-9.mol

Synonyms:3-NITRO-7-AZAINDOLE;3-nitro-1H-pyrrolo[2,3-b]pyridine;1H-Pyrrolo[2,3-b]pyridine, 3-nitro-

Chemical Property of 3-Nitro-7-azaindole

Chemical Property:

• Vapor Pressure: 8.03E-06mmHg at 25°C
• Melting Point: >300 °C
• Boiling Point: 386.2°Cat760mmHg
• PKA: 3.13±0.20(Predicted)
• Flash Point: 187.3°C
• PSA: 74.50000
• Density: 1.525g/cm³
• LogP: 1.99430
• Storage Temp.: 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

3-Nitro-7-azaindole ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 22-36
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Nitro-7-azaindole

There total 2 articles about 3-Nitro-7-azaindole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

7-Azaindole (271-63-6) → 3-nitro-1H-pyrrolo<2,3-b>pyridine (23709-47-9)

Guidance literature:

With nitric acid;

DOI:10.1021/ja01512a058

Reference yield:

→ 3-nitro-1H-pyrrolo<2,3-b>pyridine (23709-47-9)

Guidance literature:

nach Robison et al.;

DOI:10.1039/j39690001505

Reference yield: 91.0%

3-nitro-1H-pyrrolo<2,3-b>pyridine (23709-47-9) → ethyl 2-(3-nitropyrrolo<2,3-b>pyridin-1-yl) ethanoate (127988-45-8)

Guidance literature:

With potassium carbonate; In acetonitrile; for 1.5h; Heating;

DOI:10.1016/0223-5234(89)90056-1

upstream raw materials:

7-Azaindole

Downstream raw materials:

3-amino-1H-pyrrolo[2,3-b]pyridine

1-methyl-3-nitropyrrolo<2,3-b>pyridine

1-(2-Bromo-ethyl)-3-nitro-1H-pyrrolo[2,3-b]pyridine

3-(3-Nitro-pyrrolo[2,3-b]pyridin-1-yl)-propane-1,2-diol

Refernces

• 1、 Cheng, Qiang,Zhang, Fang,Cai, Yue,Guo, Yin-Long,You, Shu-Li. "Stereodivergent Synthesis of Tetrahydrofuroindoles through Pd-Catalyzed Asymmetric Dearomative Formal [3+2] Cycloaddition". supporting information. p. 2134 - 2138. Retrieved 2018/02/06.