Sodium 2-glycerophosphate pentahydrate

Base Information

• Chemical Name: Sodium 2-glycerophosphate pentahydrate
• CAS No.: 13408-09-8
• Molecular Formula: C₃H₇O₆P*5H₂O*2Na
• Molecular Weight: 306.115
• Hs Code.: 29199000
• European Community (EC) Number: 212-464-3,686-239-7
• UNII: 5JIY5MMX0E
• DSSTox Substance ID: DTXSID60158536
• Wikipedia: Glycerol_2-phosphate
• Wikidata: Q27262456
• Mol file: 13408-09-8.mol

Synonyms:2-glycerophosphoric acid;beta-glycerol phosphate;beta-glycerophosphate;beta-glycerophosphoric acid;beta-glycerophosphoric acid, calcium salt;beta-glycerophosphoric acid, calcium salt (1:1);beta-glycerophosphoric acid, disodium salt;beta-glycerophosphoric acid, iron salt;beta-glycerophosphoric acid, iron(3+) salt(3:2);beta-glycerophosphoric acid, sodium salt;Glycerol 2-phosphate

Chemical Property of Sodium 2-glycerophosphate pentahydrate

Chemical Property:

• Melting Point: >300°C
• Boiling Point: 488.2 °C at 760 mmHg
• Flash Point: 249.1 °C
• PSA: 111.69000
• LogP: 0.28450
• Storage Temp.: 2-8°C
• Solubility.: H2O: 0.1 g/mL, clear, colorless
• Water Solubility.: Soluble in water.
• Hydrogen Bond Donor Count: 7
• Hydrogen Bond Acceptor Count: 11
• Rotatable Bond Count: 3
• Exact Mass: 306.03038692
• Heavy Atom Count: 17
• Complexity: 113

Purity/Quality:

98%, ^*data from raw suppliers

β-Glycerol phosphate disodium salt pentahydrate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Chemical Classes: Metals -> Organic Acids, Metal Salts
• Canonical SMILES: C(C(CO)OP(=O)([O-])[O-])O.O.O.O.O.O.[Na+].[Na+]
• Description: β-Glycerophosphate is a protein phosphatase inhibitor that acts as a phosphate group donor in matrix mineralization studies. It promotes bone matrix mineralization when delivered to osteoblasts by providing a source of phosphate ions. β-Glycerophosphate (10 mM) accelerates calcification of cultured vascular smooth muscle cells through an alkaline phosphatase-related mechanism.
• Uses: β-Glycerol Phosphate was shown to have promoted mineralization in vitro by modulating bone cell metabolic activity and/or serving as a local source of inorganic phosphate ions. Sodium β-glycerophosphate pentahydrate is used as a phosphatase inhibitor. It promotes bone matrix mineralization while delivering to osteoblasts by providing a source of phosphate ions. It is used in the development of hydrogels and scaffolds, which finds applications in tissue engineering and cell growth. It is used as an additive in isolation mediums by providing phosphate ions to isolate. It is utilized to promote mineralization in vitro by modulating bone cell metabolic activity.

Technology Process of Sodium 2-glycerophosphate pentahydrate

There total 2 articles about Sodium 2-glycerophosphate pentahydrate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

glycerol (56-81-5,25618-55-7,64333-26-2,8013-25-0) → sodium β-glycerophosphate (13408-09-8,69881-75-0)

Guidance literature:

at 175 - 180 ℃; im Vakuum und nachfolgende Neutralisation mit Natronlauge; durch Verseifung des entstehenden Diglycerinphosphats mit Natronlauge eine weitere Menge der Dinatriumsalz der α- und β-Verbindung wird gewonnen;

Reference yield:

→ sodium β-glycerophosphate (13408-09-8,69881-75-0)

Guidance literature:

With sodium carbonate;

Reference yield:

water (7732-18-5) + sodium β-glycerophosphate (13408-09-8,69881-75-0) + epichlorohydrin (106-89-8,24969-06-0,13403-37-7) → phosphoric acid-(β,β'-dihydroxy-isopropyl ester)-(2,3-dihydroxy-propyl ester) (145094-05-9)

Guidance literature:

at 60 ℃; dann Eintragen von Silbersulfat in die siedende Loesung;

upstream raw materials:

glycerol

Downstream raw materials:

phosphoric acid-(β,β'-dihydroxy-isopropyl ester)-(2,3-dihydroxy-propyl ester)