2-nitro-3,4,5-trifluorobenzoyl chloride

Base Information

• Chemical Name: 2-nitro-3,4,5-trifluorobenzoyl chloride
• CAS No.: 173589-92-9
• Molecular Formula: C₇HClF₃NO₃
• Molecular Weight: 239.538
• Hs Code.: 2916399090
• Mol file: 173589-92-9.mol

Synonyms:2-nitro-3,4,5-trifluorobenzoyl chloride

Chemical Property of 2-nitro-3,4,5-trifluorobenzoyl chloride

Chemical Property:

• Boiling Point: 299.0±35.0 °C(Predicted)
• Density: 1.707±0.06 g/cm3(Predicted)

Purity/Quality:

97% ^*data from raw suppliers

2-Nitro-3,4,5-trifluorobenzoyl chloride ^*data from reagent suppliers

Safty Information:

• Hazard Codes: C

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-nitro-3,4,5-trifluorobenzoyl chloride

There total 1 articles about 2-nitro-3,4,5-trifluorobenzoyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3,4,5-trifluorobenzoic acid (121602-93-5,255875-61-7) → 2-nitro-3,4,5-trifluorobenzoyl chloride (173589-92-9)

Guidance literature:

With thionyl chloride; sulfuric acid; nitric acid;

Reference yield: 98.0%

ethyl 3-(1-t-butyldimethylsilyloxyprop-2-ylamino)acrylate (178233-28-8) + dichloromethane (75-09-2) + 2-nitro-3,4,5-trifluorobenzoyl chloride (173589-92-9) → ethyl 2-(2-nitro-3,4,5-trifluoro) benzoyl-3-(1-t-butyldimethylsilyloxyprop-2-ylamino) acrylate (178233-30-2)

Guidance literature:

With triethylamine; In water; acetonitrile;

Reference yield: 91.0%

2-nitro-3,4,5-trifluorobenzoyl chloride (173589-92-9) + (+)-ethyl 3-[(1-acetoxyprop-2(S)-yl)amino]acrylate → (+)-ethyl 2-(2-nitro-3,4,5-trifluorobenzoyl)-3-[(1-acetoxyprop-2(S)-yl)amino]acrylate (188058-75-5)

Guidance literature:

With triethylamine; In acetonitrile; for 0.5h; Heating;

upstream raw materials:

3,4,5-trifluorobenzoic acid

Downstream raw materials:

(+)-ethyl 2-(2-nitro-3,4,5-trifluorobenzoyl)-3-[(1-acetoxyprop-2(S)-yl)amino]acrylate

ethyl 2-(2-nitro-3,4,5-trifluoro) benzoyl-3-(1-t-butyldimethylsilyloxyprop-2-ylamino) acrylate

Refernces