Oxazolo[5,4-b]pyridin-2(1H)-one

Base Information

• Chemical Name: Oxazolo[5,4-b]pyridin-2(1H)-one
• CAS No.: 118767-92-3
• Molecular Formula: C6H4 N2 O2
• Molecular Weight: 136.11
• Hs Code.: 2934999090
• DSSTox Substance ID: DTXSID90449500
• Mol file: 118767-92-3.mol

Synonyms:oxazolopyridinone

Chemical Property of Oxazolo[5,4-b]pyridin-2(1H)-one

Chemical Property:

• PSA: 59.15000
• LogP: 0.92840
• Storage Temp.: 2-8°C
• XLogP3: 0.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 136.027277375
• Heavy Atom Count: 10
• Complexity: 160

Purity/Quality:

98%min ^*data from raw suppliers

Oxazolo[5,4-b]pyridin-2(1H)-one 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC2=C(N=C1)OC(=O)N2

Technology Process of Oxazolo[5,4-b]pyridin-2(1H)-one

There total 5 articles about Oxazolo[5,4-b]pyridin-2(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

2-hydroxy-3-aminopyridine (33630-99-8) + bis(trichloromethyl) carbonate (triphosgene) → oxazolo[5,4-b]pyridin-2(3H)-one (118767-92-3)

Guidance literature:

With triethylamine; In tetrahydrofuran; dichloromethane;

Reference yield: 78.0%

bis(trichloromethyl) carbonate (32315-10-9) + 3-amino-2-pyridone (33630-99-8) → oxazolo[5,4-b]pyridin-2(3H)-one (118767-92-3)

Guidance literature:

With triethylamine; In tetrahydrofuran; dichloromethane; at -78 ℃; for 6h;

DOI:10.1016/S0040-4039(00)61315-1

Reference yield: 50.0%

3-amino-2-pyridone (33630-99-8) + 1,1'-carbonyldiimidazole (530-62-1) → oxazolo[5,4-b]pyridin-2(3H)-one (118767-92-3)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; dichloromethane; at -78 ℃; for 6h;

DOI:10.1016/S0040-4039(00)61315-1

upstream raw materials:

(2-hydroxy-[3]pyridyl)-carbamic acid ethyl ester

bis(trichloromethyl) carbonate

3-amino-2-pyridone

1,1'-carbonyldiimidazole

Downstream raw materials:

1-<2-methyl-3-<4-(4-fluorophenyl)-1-piperazinyl>propyl>oxazolo<5,4-b>pyridin-2(1H)-one

3-amino-2-pyridone

1-Methyl-1H-oxazolo[5,4-b]pyridin-2-one

1-(4-Nitro-benzyl)-1H-oxazolo[5,4-b]pyridin-2-one

Refernces

• 1、 -. "Oxazolopyridine compounds, compositions and use". . . Retrieved 2008/06/13.