2-AMINO-5-BROMO-3-MORPHOLIN-4-YLPYRAZINE

Base Information

• Chemical Name: 2-AMINO-5-BROMO-3-MORPHOLIN-4-YLPYRAZINE
• CAS No.: 117719-17-2
• Molecular Formula: C8H11BrN4O
• Molecular Weight: 259.106
• Hs Code.: 2934999090
• Mol file: 117719-17-2.mol

Synonyms:Pyrazinamine,5-bromo-3-(4-morpholinyl)- (9CI);2-Amino-5-bromo-3-morpholinylpyrazine;5-Bromo-3-morpholinopyrazin-2-amine;

Chemical Property of 2-AMINO-5-BROMO-3-MORPHOLIN-4-YLPYRAZINE

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.631
• Boiling Point: 417.029 °C at 760 mmHg
• Flash Point: 206.012 °C
• PSA: 64.27000
• Density: 1.643 g/cm³
• LogP: 1.30410
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

98%min ^*data from raw suppliers

5-Bromo-3-morpholinopyrazin-2-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-AMINO-5-BROMO-3-MORPHOLIN-4-YLPYRAZINE

There total 1 articles about 2-AMINO-5-BROMO-3-MORPHOLIN-4-YLPYRAZINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.1%

morpholine (110-91-8,99108-56-2) + 2-amino-3,5-dibromopyrazine (24241-18-7) → 5-bromo-3-morpholin-4-ylpyrazin-2-ylamine (117719-17-2)

Guidance literature:

morpholine; 2-amino-3,5-dibromopyrazine; at 120 ℃; for 48h;

With sodium hydrogencarbonate; In dichloromethane; water;

Reference yield: 97.0%

5-bromo-3-morpholin-4-ylpyrazin-2-ylamine (117719-17-2) + mesitylenesulfonylhydroxylamine (36016-40-7) → 1,2-diamino-5-bromo-3-morpholinopyrazin-1-ium 2,4,6-trimethylbenzenesulfonate (1316761-30-4)

Guidance literature:

In dichloromethane; at 0 - 20 ℃;

Reference yield: 90.0%

5-bromo-3-morpholin-4-ylpyrazin-2-ylamine (117719-17-2) + (2-aminopyrimidin-5-yl)boronic acid (936250-22-5) → C12H15N7O (1252598-10-9)

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate; In 1,2-dimethoxyethane; at 130 ℃; for 0.166667h; Microwave irradiation;

DOI:10.1016/j.tetlet.2011.12.077

upstream raw materials:

morpholine

2-amino-3,5-dibromopyrazine

Downstream raw materials:

methyl 3-(3-(2,4,4-trimethylpentan-2-ylamino)-6-(3-methoxyphenyl)-8-morpholinoimidazo[1,2-a]pyrazin-2-yl)propanoate

methyl 3-(3-amino-6-(3-methoxyphenyl)-8-morpholino-imidazo[1,2-a]pyrazin-2-yl)propanoate

C₂₀H₂₁N₅O₃

methyl 3-((methoxycarbonyl)methyl)-6-(3-methoxyphenyl)-8-morpholinoimidazo[1,2-a]pyrazine-2-carboxylate

Refernces

• 1、 -. "DUAL KINASE-BROMODOMAIN INHIBITORS". Page/Page column 95; 140. . Retrieved 2021/12/12.
• 2、 -. "A 2 - amino pyrazine derivatives of preparation method". Paragraph 0012; 0013; 0014. . Retrieved 2018/10/19.