C₁₆H₂₈O₃Si

Base Information

• Chemical Name: C₁₆H₂₈O₃Si
• CAS No.: 1482494-94-9
• Molecular Formula: C₁₆H₂₈O₃Si
• Molecular Weight: 296.482
• Mol file: 1482494-94-9.mol

Synonyms:C₁₆H₂₈O₃Si

Chemical Property of C₁₆H₂₈O₃Si

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₆H₂₈O₃Si

There total 6 articles about C₁₆H₂₈O₃Si which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

C16H28O2Si (1482494-93-8) → C16H28O3Si (1482494-94-9)

Guidance literature:

With [bis(acetoxy)iodo]benzene; water; In acetonitrile; at 0 ℃;

DOI:10.1021/ol402913m

Reference yield:

4-(4-hydroxyphenyl)-2-oxobutane (5471-51-2) → C16H28O3Si (1482494-94-9)

Guidance literature:

Multi-step reaction with 6 steps

1: sodium tetrahydroborate / methanol / 1.5 h / 0 - 20 °C / Inert atmosphere

2: Lipase PS / acetonitrile / 72 h / 20 °C / Sealed tube; Enzymatic reaction

3: potassium carbonate / methanol / 20 °C / Inert atmosphere

4: dmap; 1H-imidazole / dichloromethane / 0 - 20 °C / Inert atmosphere

5: potassium carbonate / methanol / 3 h / Inert atmosphere; Reflux

6: [bis(acetoxy)iodo]benzene; water / acetonitrile / 0 °C

With 1H-imidazole; dmap; sodium tetrahydroborate; Lipase PS; [bis(acetoxy)iodo]benzene; water; potassium carbonate; In methanol; dichloromethane; acetonitrile;

DOI:10.1021/ol402913m

Reference yield:

(R)-(+)-4-(4'-hydroxyphenyl)-2-butyl acetate (129752-69-8) → C16H28O3Si (1482494-94-9)

Guidance literature:

Multi-step reaction with 4 steps

1: potassium carbonate / methanol / 20 °C / Inert atmosphere

2: dmap; 1H-imidazole / dichloromethane / 0 - 20 °C / Inert atmosphere

3: potassium carbonate / methanol / 3 h / Inert atmosphere; Reflux

4: [bis(acetoxy)iodo]benzene; water / acetonitrile / 0 °C

With 1H-imidazole; dmap; [bis(acetoxy)iodo]benzene; water; potassium carbonate; In methanol; dichloromethane; acetonitrile;

DOI:10.1021/ol402913m

upstream raw materials:

4-(4-hydroxyphenyl)-2-oxobutane

rac-rhododendrol

(R)-(+)-4-(4'-hydroxyphenyl)-2-butyl acetate

(R)-rhododendrol

Downstream raw materials:

(R)-4-(3-hydroxybutyl)-4-hydroxy-2,5-cyclohexadien-1-one

Refernces