HEXAKIS-6-(DIMETHYL-TERT-BUTYLSILYL)-ALPHA-CYCLODEXTRIN

Base Information

• Chemical Name: HEXAKIS-6-(DIMETHYL-TERT-BUTYLSILYL)-ALPHA-CYCLODEXTRIN
• CAS No.: 118646-79-0
• Molecular Formula: C72H144 O30 Si6
• Molecular Weight: 1658.43
• Hs Code.: 29400000
• Mol file: 118646-79-0.mol

Synonyms:2,4,7,9,12,14,17,19,22,24,27,29-Dodecaoxaheptacyclo[26.2.2.23,6.28,11.213,16.218,21.223,26]dotetracontane,a-cyclodextrin deriv.;Hexakis(6-O-tert-butyldimethylsilyl)cyclomaltohexaose;Hexakis(6-dimethyl-tert-butylsilyl)-a-cyclodextrin

Chemical Property of HEXAKIS-6-(DIMETHYL-TERT-BUTYLSILYL)-ALPHA-CYCLODEXTRIN

Chemical Property:

• Melting Point: 320 °C
• PSA: 408.90000
• LogP: 5.12220

Purity/Quality:

98%min ^*data from raw suppliers

6-Tert-butyldimethylsilyl-a-cyclodextrin ^*data from reagent suppliers

Safty Information:

• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of HEXAKIS-6-(DIMETHYL-TERT-BUTYLSILYL)-ALPHA-CYCLODEXTRIN

There total 1 articles about HEXAKIS-6-(DIMETHYL-TERT-BUTYLSILYL)-ALPHA-CYCLODEXTRIN which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

tert-butyldimethylsilyl chloride (18162-48-6) + alpha cyclodextrin (10016-20-3) → 6A,6B,6C,6D,6E,6F-Hexa-O-(tert-butyldimethylsiloxy)-α-cyclodextrin (118646-79-0)

Guidance literature:

With pyridine; at 0 - 20 ℃;

DOI:10.1021/jo061990v

Reference yield: 90.0%

benzyl bromide (100-39-0) + 6A,6B,6C,6D,6E,6F-Hexa-O-(tert-butyldimethylsiloxy)-α-cyclodextrin (118646-79-0) → C156H216O30Si6

Guidance literature:

6^A,6^B,6^C,6^D,6^E,6^F-Hexa-O-(tert-butyldimethylsiloxy)-α-cyclodextrin; With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 1h;

benzyl bromide; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 16h;

DOI:10.2174/157017861110141117121751

Reference yield: 75.0%

ibuprofen (15687-27-1,58560-75-1) + 6A,6B,6C,6D,6E,6F-Hexa-O-(tert-butyldimethylsiloxy)-α-cyclodextrin (118646-79-0) → C13H18O2*C72H144O30Si6 (1198110-01-8)

Guidance literature:

In N,N-dimethyl-formamide; at 20 ℃; for 24h;

DOI:10.1134/S1070363209060231

upstream raw materials:

tert-butyldimethylsilyl chloride

alpha cyclodextrin

Downstream raw materials:

hexakis(2-O-benzyl-6-O-tert-butyldimethylsilyl)cyclomaltohexaose

C₁₃H₁₈O₂*C₇₂H₁₄₄O₃₀Si₆

per-6-O-(tert-butyl)(dimethyl)silyl-per(2,3-di-O-acetyl)-α-cyclodextrin

Refernces

• 1、 Cravotto, Giancarlo,Mendicuti, Francisco,Martina, Katia,Tagliapietra, Silvia,Robaldo, Bruna,Barge, Alessandro. "A new access to homo- and heterodimers of α-, β-, and γ-cyclodextrin by a microwave-promoted huisgen cycloaddition". . p. 2642 - 2646. Retrieved 2008.
• 2、 Dubes, Alix,Degobert, Ghania,Fessi, Hatem,Parrot-Lopez, Helene. "Synthesis and characterisation of sulfated amphiphilic α-, β- and γ-cyclodextrins: Application to the complexation of acyclovir". . p. 2185 - 2193. Retrieved 2003.
• 3、 Anderson, Harry L.,Caycedo-Soler, Felipe,Frawley, Andrew T.,Huelga, Susana F.,Kendrick, William J.,Mattioni, Andrea,Plenio, Martin B.,Pruchyathamkorn, Jiratheep. "A Complex Comprising a Cyanine Dye Rotaxane and a Porphyrin Nanoring as a Model Light-Harvesting System". . p. 16455 - 16458. Retrieved 2020.
• 4、 McKee, James A.,Green, Thomas K.. "Synthesis of 2,3-O-dibenzyl-6-O-sulfobutyl-α and β cyclodextrins: new chiral surfactants for capillary electrophoresis". . p. 4451 - 4454. Retrieved 2015.
• 5、 Grachev,Edunov,Kurochkina,Levina,Nifant'ev. "Acetylation of secondary hydroxy groups of α- and β-cyclodextrines silyl derivatives". experimental part. p. 322 - 329. Retrieved 2011/06/27.