N-((1S)-2-amino-1-{[2-(trifluoromethyl)phenyl]methyl}ethyl)-5-chloro-4-(4-bromo-1-methyl-1H-pyrazol-5-yl)-2-thiophenecarboxamide hydrochloride

Base Information

• Chemical Name: N-((1S)-2-amino-1-{[2-(trifluoromethyl)phenyl]methyl}ethyl)-5-chloro-4-(4-bromo-1-methyl-1H-pyrazol-5-yl)-2-thiophenecarboxamide hydrochloride
• CAS No.: 1047645-09-9
• Molecular Formula: C₁₉H₁₇BrClF₃N₄OS*ClH
• Molecular Weight: 558.249
• Mol file: 1047645-09-9.mol

Synonyms:N-((1S)-2-amino-1-{[2-(trifluoromethyl)phenyl]methyl}ethyl)-5-chloro-4-(4-bromo-1-methyl-1H-pyrazol-5-yl)-2-thiophenecarboxamide hydrochloride

Chemical Property of N-((1S)-2-amino-1-{[2-(trifluoromethyl)phenyl]methyl}ethyl)-5-chloro-4-(4-bromo-1-methyl-1H-pyrazol-5-yl)-2-thiophenecarboxamide hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-((1S)-2-amino-1-{[2-(trifluoromethyl)phenyl]methyl}ethyl)-5-chloro-4-(4-bromo-1-methyl-1H-pyrazol-5-yl)-2-thiophenecarboxamide hydrochloride

There total 8 articles about N-((1S)-2-amino-1-{[2-(trifluoromethyl)phenyl]methyl}ethyl)-5-chloro-4-(4-bromo-1-methyl-1H-pyrazol-5-yl)-2-thiophenecarboxamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-((1S)-2-amino-1-{[2-(trifluoromethyl)phenyl]methyl}ethyl)-5-chloro-4-(4-bromo-1-methyl-1H-pyrazol-5-yl)-2-thiophenecarboxamide (1047643-88-8) → N-((1S)-2-amino-1-{[2-(trifluoromethyl)phenyl]methyl}ethyl)-5-chloro-4-(4-bromo-1-methyl-1H-pyrazol-5-yl)-2-thiophenecarboxamide hydrochloride (1047645-09-9)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; methanol;

Reference yield:

5-Chlorothiophene-2-carboxylic acid (24065-33-6) → N-((1S)-2-amino-1-{[2-(trifluoromethyl)phenyl]methyl}ethyl)-5-chloro-4-(4-bromo-1-methyl-1H-pyrazol-5-yl)-2-thiophenecarboxamide hydrochloride (1047645-09-9)

Guidance literature:

Multi-step reaction with 8 steps

1: iron(III) chloride; bromine / acetic acid / 168 h / 25 °C / Heating / reflux

2: N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate / dichloromethane / 1 h / 25 °C

3: hydrazine / tetrahydrofuran; methanol / 12 h

4: tetrahydrofuran / 0.5 h

5: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 14 h / 80 °C

6: N-Bromosuccinimide / tetrahydrofuran / 1 h / 70 °C

7: trifluoroacetic acid / dichloromethane / 0.5 h / 25 °C

8: hydrogenchloride / 1,4-dioxane; methanol

With hydrogenchloride; iron(III) chloride; N-Bromosuccinimide; bromine; potassium carbonate; N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; trifluoroacetic acid; hydrazine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; acetic acid;

Reference yield:

4-bromo-thiophene-2-carboxylic acid (16694-18-1) → N-((1S)-2-amino-1-{[2-(trifluoromethyl)phenyl]methyl}ethyl)-5-chloro-4-(4-bromo-1-methyl-1H-pyrazol-5-yl)-2-thiophenecarboxamide hydrochloride (1047645-09-9)

Guidance literature:

Multi-step reaction with 8 steps

1: N-chloro-succinimide / N,N-dimethyl-formamide / 10 h / 50 °C

2: N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate / dichloromethane / 1 h / 25 °C

3: hydrazine / tetrahydrofuran; methanol / 12 h

4: tetrahydrofuran / 0.5 h

5: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 14 h / 80 °C

6: N-Bromosuccinimide / tetrahydrofuran / 1 h / 70 °C

7: trifluoroacetic acid / dichloromethane / 0.5 h / 25 °C

8: hydrogenchloride / 1,4-dioxane; methanol

With hydrogenchloride; N-chloro-succinimide; N-Bromosuccinimide; potassium carbonate; N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; trifluoroacetic acid; hydrazine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide;

upstream raw materials:

N-((1S)-2-amino-1-{[2-(trifluoromethyl)phenyl]methyl}ethyl)-5-chloro-4-(4-bromo-1-methyl-1H-pyrazol-5-yl)-2-thiophenecarboxamide

5-Chlorothiophene-2-carboxylic acid

4-bromo-thiophene-2-carboxylic acid

4-bromo-5-chlorothiophene-2-carboxylic acid

Refernces