p-fluorophenyl deuterated methyl ether

Base Information

• Chemical Name: p-fluorophenyl deuterated methyl ether
• CAS No.: 101493-80-5
• Molecular Formula: C₇H₇FO
• Molecular Weight: 129.107
• Mol file: 101493-80-5.mol

Synonyms:p-fluorophenyl deuterated methyl ether

Chemical Property of p-fluorophenyl deuterated methyl ether

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of p-fluorophenyl deuterated methyl ether

There total 2 articles about p-fluorophenyl deuterated methyl ether which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

potassium deuterated methoxide (6552-74-5) + 4-fluorophenyl tosylate (1582-01-0) → p-fluorophenyl deuterated methyl ether (101493-80-5)

Guidance literature:

In acetonitrile; at 45 ℃; for 18.5h;

Reference yield: 25.0%

4-Fluorophenol (371-41-5) + iodomethane-d3 (865-50-9) → p-fluorophenyl deuterated methyl ether (101493-80-5)

Guidance literature:

With potassium carbonate; In acetone; at 20 ℃; for 24h; Sealed tube;

Reference yield: 30.0%

Triisopropyl borate (5419-55-6) + p-fluorophenyl deuterated methyl ether (101493-80-5) → 5-fluoro-2-methoxy-d3-phenylboronic acid (1287739-63-2)

Guidance literature:

p-fluorophenyl deuterated methyl ether; With n-butyllithium; In tetrahydrofuran; hexane; at -60 ℃; for 3h;

Triisopropyl borate; In tetrahydrofuran; hexane; at -78 - 20 ℃;

With hydrogenchloride; In tetrahydrofuran; hexane; water;

upstream raw materials:

4-Fluorophenol

iodomethane-d3

potassium deuterated methoxide

4-fluorophenyl tosylate

Downstream raw materials:

5-fluoro-2-methoxy-d3-phenylboronic acid

1-(5'-fluoro-2'-methoxy-d3-biphenyl-3-yl)-5-trifluoromethyl-1H-benzo[d]imidazole

Refernces

• 1、 -. "SUBSITITUTED BENZIMIDAZOLES". Page/Page column 49. . Retrieved 2011/05/05.