3-Cyclopentene-1-carbonyl chloride, 1,2,2-trimethyl- (9CI)

Base Information

• Chemical Name: 3-Cyclopentene-1-carbonyl chloride, 1,2,2-trimethyl- (9CI)
• CAS No.: 114805-50-4
• Molecular Formula: C₉H₁₃ClO
• Molecular Weight: 172.655
• Mol file: 114805-50-4.mol

Synonyms:3-Cyclopentene-1-carbonyl chloride, 1,2,2-trimethyl- (9CI)

Chemical Property of 3-Cyclopentene-1-carbonyl chloride, 1,2,2-trimethyl- (9CI)

Chemical Property:

• PSA: 17.07000
• LogP: 2.74420

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Cyclopentene-1-carbonyl chloride, 1,2,2-trimethyl- (9CI)

There total 1 articles about 3-Cyclopentene-1-carbonyl chloride, 1,2,2-trimethyl- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(1R)-1,2,2-trimethylcyclopent-3-ene-1-carboxylic acid (54812-06-5) → (R)-1,2,2-Trimethyl-cyclopent-3-enecarbonyl chloride (114805-50-4)

Guidance literature:

With oxalyl dichloride;

DOI:10.1021/ja00154a053

Reference yield:

(R)-1,2,2-Trimethyl-cyclopent-3-enecarbonyl chloride (114805-50-4) → (1R)-1,2,2-trimethylcyclopent-3-ene carboxamide (173411-22-8)

Guidance literature:

With ammonium hydroxide; Yield given;

DOI:10.1021/ja00154a053

Reference yield:

(R)-1,2,2-Trimethyl-cyclopent-3-enecarbonyl chloride (114805-50-4) → (1R,4R)-4,5,5-Trimethyl-2-aza-bicyclo[2.2.1]heptan-3-one (173411-24-0,442913-23-7)

Guidance literature:

Multi-step reaction with 5 steps

1: NH₄OH

2: 1,2-dichloro-ethane

3: 1,2-dichloro-ethane / 65 °C

4: 1.) NaH, 2.) NBS / 1.) THF, RT, 2.) THF, -78 deg C

5: 1.) H₂, 2.) NaOH / 1.) 10percent Pd/C / 1.) 3.5 atm

With ammonium hydroxide; sodium hydroxide; N-Bromosuccinimide; hydrogen; sodium hydride; palladium on activated charcoal; In 1,2-dichloro-ethane;

DOI:10.1021/ja00154a053

upstream raw materials:

(1R)-1,2,2-trimethylcyclopent-3-ene-1-carboxylic acid

Downstream raw materials:

(1R)-1,2,2-trimethylcyclopent-3-ene carboxamide

(1R,4R)-4,5,5-Trimethyl-2-aza-bicyclo[2.2.1]heptan-3-one

Refernces