1-cyclopentyl-3-phenyl-1-propanol

Base Information

• Chemical Name: 1-cyclopentyl-3-phenyl-1-propanol
• CAS No.: 202596-55-2
• Molecular Formula: C₁₄H₂₀O
• Molecular Weight: 204.312
• Mol file: 202596-55-2.mol

Synonyms:1-cyclopentyl-3-phenyl-1-propanol

Chemical Property of 1-cyclopentyl-3-phenyl-1-propanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-cyclopentyl-3-phenyl-1-propanol

There total 8 articles about 1-cyclopentyl-3-phenyl-1-propanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

cis-2-(3-butenyl)-3-(2-phenylethyl)oxirane (127208-26-8,127208-28-0) → 1-cyclopentyl-3-phenyl-1-propanol (202596-55-2)

Guidance literature:

cis-2-(3-butenyl)-3-(2-phenylethyl)oxirane; With zirconocene hydrochloride; In dichloromethane; at 20 ℃; for 0.5h;

With boron trifluoride diethyl etherate; In dichloromethane; at 0 - 20 ℃; for 2h;

DOI:10.1016/S0040-4020(97)10340-4

Reference yield: 69.0%

3-phenyl-propionaldehyde (104-53-0) + cyclopentyl iodide (1556-18-9) → 1-cyclopentyl-3-phenyl-1-propanol (202596-55-2)

Guidance literature:

With indium; iodine; silver(I) iodide; In water; at 20 ℃; for 48h;

DOI:10.1021/jo8000589

Reference yield: 64.0%

1-cyclopentylethan-1-ol (52829-98-8) + benzyl alcohol (100-51-6,185532-71-2) → 1-cyclopentyl-3-phenyl-1-propanol (202596-55-2)

Guidance literature:

With C₂₃H₂₁MnN₂O₃P⁽¹⁺⁾*Br^(1-); potassium tert-butylate; In toluene; at 135 ℃; for 20h; chemoselective reaction; Inert atmosphere; Green chemistry;

DOI:10.1002/cssc.201801660

upstream raw materials:

phenethylmagnesium bromide

cyclopentanealdehyde

cyclohexane-1,2-epoxide

cis-2-(3-butenyl)-3-(2-phenylethyl)oxirane

Downstream raw materials:

1-cyclopentyl-3-phenylpropan-1-one

Refernces

• 1、 Cruz, Cole L.,Montgomery, John. "Nickel-catalyzed reductive coupling of unactivated alkyl bromides and aliphatic aldehydes". . p. 11995 - 12000. Retrieved 2021/09/28.
• 2、 -. "INHIBITORS OF HEPATITIS C VIRUS RNA-DEPENDENT RNA POLYMERASE, AND COMPOSITIONS AND TREATMENTS USING THE SAME". Page/Page column 55. . Retrieved 2010/02/07.