(2-Methoxypyridin-3-yl)methanol

Base Information

• Chemical Name: (2-Methoxypyridin-3-yl)methanol
• CAS No.: 112197-16-7
• Molecular Formula: C7H9NO2
• Molecular Weight: 139.154
• Hs Code.: 2933399090
• European Community (EC) Number: 838-788-0
• DSSTox Substance ID: DTXSID10442639
• Nikkaji Number: J3.264.673E
• Wikidata: Q72485341
• Mol file: 112197-16-7.mol

Synonyms:(2-methoxypyridin-3-yl)methanol;112197-16-7;(2-methoxy-3-pyridinyl)methanol;3-Pyridinemethanol,2-methoxy-(9ci);(2-Methoxy-pyridin-3-yl)-methanol;3-(Hydroxymethyl)-2-methoxypyridine;MFCD09880283;2-METHOXY-3-HYDROXYMETHYLPYRIDINE;[2-methoxy-pyridin-3-yl]-methanol;2-methoxy-3-picolyl alcohol;SCHEMBL18440;2-Methoxypyridine 3-methanol;3-Pyridinemethanol,2-methoxy-;DTXSID10442639;OFWONXXWLCHTSR-UHFFFAOYSA-N;2-METHOXYPYRIDINE-3-METHANOL;CL0061;AKOS005072914;AM90668;GD-0733;PB20446;AC-23282;SY039815;CS-0031357;FT-0681308;EN300-174548;8-(2-Aminoethylamino)-1-naphthalenesulfonicacid;J-500842;Z800297974

Chemical Property of (2-Methoxypyridin-3-yl)methanol

Chemical Property:

• Vapor Pressure: 0.019mmHg at 25°C
• Melting Point: lowmeltsolid°
• Refractive Index: 1.534
• Boiling Point: 241.865 °C at 760 mmHg
• PKA: 13.20±0.10(Predicted)
• Flash Point: 100.077 °C
• PSA: 42.35000
• Density: 1.155 g/cm³
• LogP: 0.58250
• Storage Temp.: Inert atmosphere,Room Temperature
• XLogP3: 0.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 139.063328530
• Heavy Atom Count: 10
• Complexity: 97.6

Purity/Quality:

98%,99%, ^*data from raw suppliers

(2-Methoxypyridin-3-yl)methanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=C(C=CC=N1)CO

Technology Process of (2-Methoxypyridin-3-yl)methanol

There total 8 articles about (2-Methoxypyridin-3-yl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-methoxynicotinic acid methyl ester (67367-26-4) → (2-methoxy-pyridin-3-yl)-methanol (112197-16-7)

Guidance literature:

2-methoxynicotinic acid methyl ester; With lithium borohydride; In tetrahydrofuran; at 70 ℃; for 2h;

With water; ammonium chloride; In tetrahydrofuran;

Reference yield: 99.0%

2-methoxynicotinaldehyde (71255-09-9) → (2-methoxy-pyridin-3-yl)-methanol (112197-16-7)

Guidance literature:

With sodium tetrahydroborate; In tetrahydrofuran; at 20 ℃; for 1h;

Reference yield: 84.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 2-methoxypyridin-3-yl-boronic acid (163105-90-6) → (2-methoxy-pyridin-3-yl)-methanol (112197-16-7)

Guidance literature:

With bis(η3-allyl-μ-chloropalladium(II)); 1-(2-bromophenyl)-3-(2,6-diisopropylphenyl)-4,5-dihydroimidazolinium chloride; In tetrahydrofuran; water; at 100 ℃; for 2h; Inert atmosphere; Sealed tube;

DOI:10.1016/j.tet.2014.11.051

upstream raw materials:

1,3,5-Trioxan

2-methoxypyridine

2-methoxynicotinic acid methyl ester

2-methoxynicotinaldehyde

Downstream raw materials:

3-(4'-bromo-biphenyl-4-yloxymethyl)-2-methoxy-pyridine

2-(2-methoxy-3-pyridyl)acetic acid

(2-methoxypyridin-3-yl)acetonitrile

2-((2-methoxy-3-pyridinyl)methyl)piperazine

Refernces

• 1、 Whitehouse, Andrew J.,Thomas, Sherine E.,Brown, Karen P.,Fanourakis, Alexander,Chan, Daniel S.-H.,Libardo, M. Daben J.,Mendes, Vitor,Boshoff, Helena I. M.,Floto, R. Andres,Abell, Chris,Blundell, Tom L.,Coyne, Anthony G.. "Development of inhibitors against mycobacterium abscessus tRNA (m1G37) Methyltransferase (TrmD) Using Fragment-Based Approaches". supporting information. p. 7210 - 7232. Retrieved 2019/08/20.
• 2、 Huang, Qi,Zard, Samir Z.. "Modular Route to Azaindanes". supporting information. p. 3895 - 3898. Retrieved 2017/07/26.