Technology Process of 4-(1-cyclobutyl piperidin-4-yloxy)benzylamine
There total 5 articles about 4-(1-cyclobutyl piperidin-4-yloxy)benzylamine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
4-((1-cyclobutylpiperidin-4-yl)oxy)benzonitrile;
With
lithium aluminium tetrahydride;
In
tetrahydrofuran;
at 10 ℃;
for 4.66667h;
Inert atmosphere;
Reflux;
With
water;
In
tetrahydrofuran;
at 10 - 15 ℃;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 100 °C
2.1: trifluoroacetic acid / dichloromethane / 20 °C
3.1: 1,1-dichloroethane / 4 h / 20 °C
3.2: 2 h / 20 °C
4.1: lithium aluminium tetrahydride / tetrahydrofuran / 4.67 h / 10 °C / Inert atmosphere; Reflux
4.2: 10 - 15 °C
With
lithium aluminium tetrahydride; potassium carbonate; trifluoroacetic acid;
In
tetrahydrofuran; 1,1-dichloroethane; dichloromethane; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: trifluoroacetic acid / dichloromethane / 20 °C
2.1: 1,1-dichloroethane / 4 h / 20 °C
2.2: 2 h / 20 °C
3.1: lithium aluminium tetrahydride / tetrahydrofuran / 4.67 h / 10 °C / Inert atmosphere; Reflux
3.2: 10 - 15 °C
With
lithium aluminium tetrahydride; trifluoroacetic acid;
In
tetrahydrofuran; 1,1-dichloroethane; dichloromethane;
