3-Pyridinethiol,2-amino-(9CI)

Base Information

• Chemical Name: 3-Pyridinethiol,2-amino-(9CI)
• CAS No.: 110402-20-5
• Molecular Formula: C5H6N2S
• Molecular Weight: 126.182
• Hs Code.: 2933399090
• Mol file: 110402-20-5.mol

Synonyms:2-Amino-3-mercaptopyridine;2-Aminopyridine-3-thiol;

Chemical Property of 3-Pyridinethiol,2-amino-(9CI)

Chemical Property:

• Vapor Pressure: 0.0133mmHg at 25°C
• Melting Point: 158-162 °C
• Refractive Index: 1.677
• Boiling Point: 258.9 °C at 760 mmHg
• PKA: 3.26±0.48(Predicted)
• Flash Point: 110.4 °C
• PSA: 77.71000
• Density: 1.293 g/cm³
• LogP: 1.53370

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Aminopyridine-3-thiol 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Pyridinethiol,2-amino-(9CI)

There total 3 articles about 3-Pyridinethiol,2-amino-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

bis(2-amino-3-pyridyl) disulfide (125209-79-2) → 2-aminopyridine-3-thiol (110402-20-5)

Guidance literature:

With sodium tetrahydroborate; In acetonitrile; at 20 ℃; for 18h; Product distribution / selectivity;

Reference yield: 95.0%

3-(tertbutylthio)pyridin-2-amine (551950-47-1) → 2-aminopyridine-3-thiol (110402-20-5)

Guidance literature:

With hydrogenchloride; In water; for 14h; Reflux;

DOI:10.1021/acs.jmedchem.5b01627

Reference yield:

→ 2-aminopyridine-3-thiol (110402-20-5)

Guidance literature:

With sodium ethanolate; In tetrahydrofuran; at 20 ℃; for 1h; Inert atmosphere;

upstream raw materials:

3-(tertbutylthio)pyridin-2-amine

bis(2-amino-3-pyridyl) disulfide

Downstream raw materials:

bis(2-amino-3-pyridyl) disulfide

Refernces

• 1、 Janssen, Freek J.,Baggelaar, Marc P.,Hummel, Jessica J. A.,Overkleeft, Herman S.,Cravatt, Benjamin F.,Boger, Dale L.,Van Der Stelt, Mario. "Comprehensive Analysis of Structure-Activity Relationships of α-Ketoheterocycles as sn-1-Diacylglycerol Lipase α Inhibitors". . p. 9742 - 9753. Retrieved 2016/01/12.
• 2、 -. "CARBACEPHEM β-LACTAM ANTIBIOTICS". Page/Page column 94-95. . Retrieved 2009/05/30.