2-butyl-4-chloro-1-<<2'-(1H-tetrazol-5-yl)biphenyl-4-yl>methyl>imidazole-5-carboxaldehyde benzenesulfonylhydrazone

Base Information

• Chemical Name: 2-butyl-4-chloro-1-<<2'-(1H-tetrazol-5-yl)biphenyl-4-yl>methyl>imidazole-5-carboxaldehyde benzenesulfonylhydrazone
• CAS No.: 124750-13-6
• Molecular Formula: C₂₈H₂₇ClN₈O₂S
• Molecular Weight: 575.094
• Mol file: 124750-13-6.mol

Synonyms:2-butyl-4-chloro-1-<<2'-(1H-tetrazol-5-yl)biphenyl-4-yl>methyl>imidazole-5-carboxaldehyde benzenesulfonylhydrazone

Chemical Property of 2-butyl-4-chloro-1-<<2'-(1H-tetrazol-5-yl)biphenyl-4-yl>methyl>imidazole-5-carboxaldehyde benzenesulfonylhydrazone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-butyl-4-chloro-1-<<2'-(1H-tetrazol-5-yl)biphenyl-4-yl>methyl>imidazole-5-carboxaldehyde benzenesulfonylhydrazone

There total 12 articles about 2-butyl-4-chloro-1-<<2'-(1H-tetrazol-5-yl)biphenyl-4-yl>methyl>imidazole-5-carboxaldehyde benzenesulfonylhydrazone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

2-n-Butyl-4-chloro-1-[(2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl]-imidazole-5-carboxaldehyde (114798-36-6) + benzenesufonyl hydrazide (80-17-1) → 2-butyl-4-chloro-1-<<2'-(1H-tetrazol-5-yl)biphenyl-4-yl>methyl>imidazole-5-carboxaldehyde benzenesulfonylhydrazone (124750-13-6)

Guidance literature:

With sodium hydroxide; at 25 ℃; for 18h;

DOI:10.1021/jm00112a031

Reference yield:

2-(2-methoxyphenyl)-4,4-dimethyl-2-oxazoline (57598-33-1) → 2-butyl-4-chloro-1-<<2'-(1H-tetrazol-5-yl)biphenyl-4-yl>methyl>imidazole-5-carboxaldehyde benzenesulfonylhydrazone (124750-13-6)

Guidance literature:

Multi-step reaction with 7 steps

1: tetrahydrofuran / 2 h / 20 °C

2: 96 percent / pyridine, phosphorus oxychloride / 3 h / 100 °C

3: 1.) tributyltin chloride, sodium azide, 2.) 10 N aq. sodium hydroxide / 1.) toluene, reflux, 70 h, 20 deg C, 3 h

4: 92 percent / N-bromosuccinimide, dibenzoyl peroxide / CCl₄ / 3 h / Heating

5: 49 percent / potassium carbonate / dimethylformamide / 24 h / 25 °C

6: 10percent HCl / tetrahydrofuran / 4 h / 25 °C

7: 62 percent / 1.000 N aq. NaOH / 18 h / 25 °C

With pyridine; hydrogenchloride; sodium hydroxide; N-Bromosuccinimide; sodium azide; tributyltin chloride; potassium carbonate; trichlorophosphate; dibenzoyl peroxide; In tetrahydrofuran; tetrachloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm00112a031

Reference yield:

2-Cyano-4'-methylbiphenyl (114772-53-1) → 2-butyl-4-chloro-1-<<2'-(1H-tetrazol-5-yl)biphenyl-4-yl>methyl>imidazole-5-carboxaldehyde benzenesulfonylhydrazone (124750-13-6)

Guidance literature:

Multi-step reaction with 5 steps

1: 1.) tributyltin chloride, sodium azide, 2.) 10 N aq. sodium hydroxide / 1.) toluene, reflux, 70 h, 20 deg C, 3 h

2: 92 percent / N-bromosuccinimide, dibenzoyl peroxide / CCl₄ / 3 h / Heating

3: 49 percent / potassium carbonate / dimethylformamide / 24 h / 25 °C

4: 10percent HCl / tetrahydrofuran / 4 h / 25 °C

5: 62 percent / 1.000 N aq. NaOH / 18 h / 25 °C

With hydrogenchloride; sodium hydroxide; N-Bromosuccinimide; sodium azide; tributyltin chloride; potassium carbonate; dibenzoyl peroxide; In tetrahydrofuran; tetrachloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm00112a031

upstream raw materials:

2-n-Butyl-4-chloro-1-[(2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl]-imidazole-5-carboxaldehyde

benzenesufonyl hydrazide

2-(2-methoxyphenyl)-4,4-dimethyl-2-oxazoline

2-Cyano-4'-methylbiphenyl

Refernces