H-DL-PHE-NH2 HCL

Base Information

• Chemical Name: H-DL-PHE-NH2 HCL
• CAS No.: 108321-83-1
• Molecular Formula: C9H12 N2 O . Cl H
• Molecular Weight: 200.668
• Hs Code.: 2924299090
• Mol file: 108321-83-1.mol

Synonyms:Benzenepropanamide,a-amino-, monohydrochloride (9CI);Benzenepropanamide, a-amino-, monohydrochloride, (?à)-; DL-Phenylalanine amide hydrochloride; DL-Phenylalanine amidehydrochloride

Chemical Property of H-DL-PHE-NH2 HCL

Chemical Property:

• PSA: 69.11000
• LogP: 2.24430
• Storage Temp.: -15°C

Purity/Quality:

99% ^*data from raw suppliers

DL-Phenylalanine amide hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of H-DL-PHE-NH2 HCL

There total 4 articles about H-DL-PHE-NH2 HCL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 2-amino-3-phenylpropanoate hydrochloride (5619-07-8) → phenylalanine amide hydrochloride (108321-83-1)

Guidance literature:

With ammonia; In methanol; for 96h; Ambient temperature;

Reference yield:

benzyl bromide (100-39-0) → phenylalanine amide hydrochloride (108321-83-1)

Guidance literature:

Multi-step reaction with 2 steps

1: aq. NaOH; Bu₄NHSO₄ / CH₂Cl₂ / 20 °C

2: aq. hydrochloric acid

With hydrogenchloride; sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate; In dichloromethane;

DOI:10.1016/j.tetlet.2006.08.096

Reference yield:

Phenylalanine (150-30-1,25191-15-5,658-69-5,67675-33-6) → phenylalanine amide hydrochloride (108321-83-1)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride / 0 °C

2: ammonia / methanol / 0 °C

With thionyl chloride; ammonia; In methanol;

DOI:10.1002/adsc.201100923

upstream raw materials:

methyl 2-amino-3-phenylpropanoate hydrochloride

benzyl bromide

Phenylalanine

Downstream raw materials:

N-benzyloxycarbonyl-phenylalanine amide

D-(R)-phenylalanine

L-phenylalanine

methyl (2S)-2-amino-3-phenylpropanoate hydrochloride

Refernces

• 1、 Hyett, David J.,Didonè, Mara,Milcent, Thierry J.A.,Broxterman, Quirinus B.,Kaptein, Bernard. "A new method for the preparation of functionalized unnatural α-H-α-amino acid derivatives". . p. 7771 - 7774. Retrieved 2007/10/03.
• 2、 Brutsche, Andreas,Hartke, Klaus. "Dithio and Thiono Esters, 55. - Synthesis of N-Protected, Optically Active α-Amino Thiono Esters". . p. 921 - 926. Retrieved 2007/10/02.