3-(2-CARBOXY-PHENYL)-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

Base Information Edit

Chemical Name:3-(2-CARBOXY-PHENYL)-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
CAS No.:889953-29-1
Molecular Formula:C₁₆H₂₁NO₄
Molecular Weight:291.347
Hs Code.:
Mol file:889953-29-1.mol

Synonyms:2-[1-(tert-butoxycarbonyl)pyrrolidin-3-yl]benzoic acid

Suppliers and Price of 3-(2-CARBOXY-PHENYL)-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Ambeed
2-(1-(tert-butoxycarbonyl)pyrrolidin-3-yl)benzoicacid 95%
250mg
$ 317.00

Ambeed
2-(1-(tert-butoxycarbonyl)pyrrolidin-3-yl)benzoicacid 95%
100mg
$ 202.00

Ambeed
2-(1-(tert-butoxycarbonyl)pyrrolidin-3-yl)benzoicacid 95%
1g
$ 805.00

Acrotein
2-(1-(tert-Butoxycarbonyl)pyrrolidin-3-yl)benzoicacid 97%
1g
$ 538.32

Total 9 raw suppliers

Chemical Property of 3-(2-CARBOXY-PHENYL)-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Edit

Chemical Property:

Boiling Point:418.7±45.0 °C(Predicted)
PKA:4.05±0.36(Predicted)
Density:1.195±0.06 g/cm3(Predicted)
Storage Temp.:2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

2-(1-(tert-butoxycarbonyl)pyrrolidin-3-yl)benzoicacid 95% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 3-(2-CARBOXY-PHENYL)-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

There total 8 articles about 3-(2-CARBOXY-PHENYL)-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: tert-butyl 3-(2-cyanophenyl)pyrrolidine-1-carboxylic acid

: 889953-29-1
2-[1-(tert-butoxycarbonyl)pyrrolidin-3-yl]benzoic acid

Guidance literature:: With water; sodium hydroxide; In ethanol; Reagent/catalyst; Temperature; Reflux;

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 889953-29-1
2-[1-(tert-butoxycarbonyl)pyrrolidin-3-yl]benzoic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: dmap; triethylamine / dichloromethane / 0.08 h / 20 °C

1.2: 20 °C

2.1: sodium hydroxide; water / methanol / 65 °C

With dmap; water; triethylamine; sodium hydroxide; In methanol; dichloromethane;

Reference yield:

: 6630-33-7
ortho-bromobenzaldehyde

: 889953-29-1
2-[1-(tert-butoxycarbonyl)pyrrolidin-3-yl]benzoic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 5 - 10 °C / Inert atmosphere

1.2: 0.5 h / 5 - 10 °C

2.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / 12 h / Reflux

3.1: zinc; ammonium chloride / methanol / 100 °C

4.1: sodium tetrahydroborate / tetrahydrofuran / 12.5 h / 5 - 10 °C / Inert atmosphere; Reflux

5.1: sodium hydroxide / water / 120 °C / pH 10

6.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 100 °C / Inert atmosphere

7.1: sodium hydroxide; water / ethanol / Reflux

With sodium tetrahydroborate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; water; sodium hydride; ammonium chloride; 1,8-diazabicyclo[5.4.0]undec-7-ene; sodium hydroxide; zinc; In tetrahydrofuran; methanol; ethanol; water; N,N-dimethyl-formamide; mineral oil;