C₁₃H₁₉NO

Base Information

• Chemical Name: C₁₃H₁₉NO
• CAS No.: 1312589-99-3
• Molecular Formula: C₁₃H₁₉NO
• Molecular Weight: 205.3
• Mol file: 1312589-99-3.mol

Synonyms:C₁₃H₁₉NO

Chemical Property of C₁₃H₁₉NO

Chemical Property:

Purity/Quality:

>98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₃H₁₉NO

There total 9 articles about C₁₃H₁₉NO which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C13H15NO (1312589-94-8) → C13H19NO (1312589-99-3)

Guidance literature:

With borane-THF; In tetrahydrofuran; at 20 ℃; for 18h;

Reference yield:

para-methylphenylmagnesium bromide (4294-57-9) → C13H19NO (1312589-99-3)

Guidance literature:

Multi-step reaction with 8 steps

1.1: copper(I) bromide; lithium bromide / tetrahydrofuran / 18 h / 0 °C / Inert atmosphere

2.1: water; lithium hydroxide monohydrate / tetrahydrofuran / 1 h / 50 °C

2.2: pH 1

3.1: potassium hydroxide; sodium tetrahydroborate / water / 10 - 20 °C

4.1: trifluoroacetic acid / dichloromethane / 18 h / 20 °C

5.1: diisobutylaluminium hydride / dichloromethane / 2 h / -78 °C

5.2: -78 - 20 °C

6.1: triethylamine / dmap / dichloromethane / 0 - 20 °C

7.1: boron trifluoride diethyl etherate / acetonitrile / 18 h / 20 °C / Inert atmosphere

8.1: borane-THF / tetrahydrofuran / 18 h / 20 °C

With sodium tetrahydroborate; borane-THF; lithium hydroxide monohydrate; boron trifluoride diethyl etherate; water; diisobutylaluminium hydride; triethylamine; trifluoroacetic acid; potassium hydroxide; copper(I) bromide; lithium bromide; dmap; In tetrahydrofuran; dichloromethane; water; acetonitrile;

Reference yield:

ethyl 5-(4-methylphenyl)-5-oxopentanoate (42482-94-0) → C13H19NO (1312589-99-3)

Guidance literature:

Multi-step reaction with 7 steps

1.1: water; lithium hydroxide monohydrate / tetrahydrofuran / 1 h / 50 °C

1.2: pH 1

2.1: potassium hydroxide; sodium tetrahydroborate / water / 10 - 20 °C

3.1: trifluoroacetic acid / dichloromethane / 18 h / 20 °C

4.1: diisobutylaluminium hydride / dichloromethane / 2 h / -78 °C

4.2: -78 - 20 °C

5.1: triethylamine / dmap / dichloromethane / 0 - 20 °C

6.1: boron trifluoride diethyl etherate / acetonitrile / 18 h / 20 °C / Inert atmosphere

7.1: borane-THF / tetrahydrofuran / 18 h / 20 °C

With sodium tetrahydroborate; borane-THF; lithium hydroxide monohydrate; boron trifluoride diethyl etherate; water; diisobutylaluminium hydride; triethylamine; trifluoroacetic acid; potassium hydroxide; dmap; In tetrahydrofuran; dichloromethane; water; acetonitrile;

upstream raw materials:

para-methylphenylmagnesium bromide

ethyl glutaroyl chloride

ethyl 5-(4-methylphenyl)-5-oxopentanoate

5-(4-methylphenyl)-5-oxopentanoic acid

Refernces

• 1、 -. "NOVEL ANTAGONISTS FOR CCR2 AND USES THEREOF". . . Retrieved 2011/07/07.
• 2、 -. "NEW CCR2 ANTAGONISTS". . . Retrieved 2011/12/14.