benzyl N-(1-methyl-3-phenylpropyl)carbamate

Base Information

• Chemical Name: benzyl N-(1-methyl-3-phenylpropyl)carbamate
• CAS No.: 1444616-56-1
• Molecular Formula: C₁₈H₂₁NO₂
• Molecular Weight: 283.37
• Mol file: 1444616-56-1.mol

Synonyms:benzyl N-(1-methyl-3-phenylpropyl)carbamate

Chemical Property of benzyl N-(1-methyl-3-phenylpropyl)carbamate

Chemical Property:

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Technology Process of benzyl N-(1-methyl-3-phenylpropyl)carbamate

There total 1 articles about benzyl N-(1-methyl-3-phenylpropyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

O-benzyl carbamate (621-84-1) + 4-Phenyl-2-butanone (2550-26-7) → 1-phenyl-3-butanol (2344-70-9) + benzyl N-(1-methyl-3-phenylpropyl)carbamate (1444616-56-1)

Guidance literature:

With triethylsilane; sodium hexaflorophosphate; perrhenic acid anhydride; In dichloromethane; at 50 ℃; for 24h; chemoselective reaction;

DOI:10.1039/c3ob40918j

Reference yield: 100.0%

benzyl N-(1-methyl-3-phenylpropyl)carbamate (1444616-56-1) → (RS)-1-methyl-3-phenylpropylamine (22374-89-6,22148-77-2,1199266-89-1)

Guidance literature:

With hydrogen; In methanol; at 20 ℃; for 7h; chemoselective reaction;

DOI:10.1002/adsc.201700156

Reference yield: 55.0%

benzyl N-(1-methyl-3-phenylpropyl)carbamate (1444616-56-1) → 2-methyl-3,4-dihydro-2H-quinoline-1-carboxylic acid benzyl ester

Guidance literature:

With 1,1,2,2-tetramethyl-1,2-ethanediamino-N,N'-bis(3,5-di-tert-butylsalicylidene)-cobalt(II); 1,1,3,3-Tetramethyldisiloxane; 1-fluoro-2,4,6-trimethylpyridin-1-ium tetrafluoroborate; In toluene; at 20 ℃; for 16h; Inert atmosphere;

DOI:10.1021/ja507295u

upstream raw materials:

O-benzyl carbamate

4-Phenyl-2-butanone

Downstream raw materials:

(RS)-1-methyl-3-phenylpropylamine

Refernces