4H-1,4-Benzoxazin-4-amine,2,3-dihydro-(9CI)

Base Information

• Chemical Name: 4H-1,4-Benzoxazin-4-amine,2,3-dihydro-(9CI)
• CAS No.: 104255-56-3
• Molecular Formula: C8H10N2O
• Molecular Weight: 150.18
• Hs Code.: 2934999090
• Mol file: 104255-56-3.mol

Synonyms:2H-Benzo[b][1,4]oxazin-4(3H)-amine;

Chemical Property of 4H-1,4-Benzoxazin-4-amine,2,3-dihydro-(9CI)

Chemical Property:

• Vapor Pressure: 0.005mmHg at 25°C
• Refractive Index: 1.591
• Boiling Point: 276.815 °C at 760 mmHg
• Flash Point: 121.214 °C
• PSA: 38.49000
• Density: 1.192 g/cm³
• LogP: 1.52440
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

2H-Benzo[b][1,4]oxazin-4(3H)-amine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Use Description: 4H-1,4-Benzoxazin-4-amine,2,3-dihydro-(9CI) is a chemical compound with diverse applications across various fields. In organic chemistry and pharmaceutical research, it can serve as a valuable scaffold or starting material for the synthesis of complex organic molecules, including potential drug candidates. Its unique chemical structure and functional groups make it a useful building block for the development of pharmaceuticals targeting various medical conditions. Additionally, in the field of agrochemistry, this compound may find use in the synthesis of agrochemicals and pesticides, contributing to crop protection and weed control efforts in agriculture. However, the specific role and significance of 4H-1,4-Benzoxazin-4-amine,2,3-dihydro-(9CI) can vary depending on the specific research or industrial requirements within each field, underscoring its potential versatility and importance in diverse scientific and industrial applications.

Technology Process of 4H-1,4-Benzoxazin-4-amine,2,3-dihydro-(9CI)

There total 6 articles about 4H-1,4-Benzoxazin-4-amine,2,3-dihydro-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.9%

4-nitroso-3,4-dihydro-2H-benzo[b][1,4]oxazine (63169-10-8) → 3,4-Dihydro-2H-1,4-benzoxazin-4-amine (104255-56-3)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; for 2h; Inert atmosphere;

Reference yield:

1,4-benzoxazine (5735-53-5) → 3,4-Dihydro-2H-1,4-benzoxazin-4-amine (104255-56-3)

Guidance literature:

Multi-step reaction with 2 steps

1: NaNO₂, aq. H₂SO₄ / CH₂Cl₂

2: LiAlH₄ / tetrahydrofuran / 1 h / Heating

With lithium aluminium tetrahydride; sulfuric acid; sodium nitrite; In tetrahydrofuran; dichloromethane;

DOI:10.1021/jm00075a026

Reference yield:

3,4-dihydro-2H-benzo[b][1,4]oxazine hydrochloride (98491-38-4) → 3,4-Dihydro-2H-1,4-benzoxazin-4-amine (104255-56-3)

Guidance literature:

3,4-dihydro-2H-benzo[b][1,4]oxazine hydrochloride; With hydrogenchloride; sodium nitrite; In ethanol; water; at 0 ℃;

With sodium hydroxide; sodium dithionite; In ethanol; water; at 90 ℃; for 2h; Further stages.;

DOI:10.1016/j.bmc.2008.07.065

upstream raw materials:

4-nitroso-3,4-dihydro-2H-benzo[b][1,4]oxazine

1,4-benzoxazine

3,4-dihydro-2H-benzo[b][1,4]oxazine hydrochloride

3-oxo-2,3-dihydrobenzo[b]furan

Downstream raw materials:

(6bS, 11aS)-4-(1,2,6b,7,8,10,11,11a-octahydro-9H-azepino[4,5-b][1,4]oxazino[2,3,4-hi]indol-9-yl)-1-(4-fluorophenyl)-1-butanone

Refernces

• 1、 -. "BICYCLIC DERIVATIVES FOR TREATING ENDOPARASITES". Page/Page column 40; 73. . Retrieved 2020/12/29.
• 2、 -. "TRICYCLIC INDOLE MCL-1 INHIBITORS AND USES THEREOF". Paragraph 0429; 0443. . Retrieved 2016/05/19.