benzyl 5-(methylsulfonamido)-2-(trifluoromethyl)benzoate

Base Information

• Chemical Name: benzyl 5-(methylsulfonamido)-2-(trifluoromethyl)benzoate
• CAS No.: 1610862-28-6
• Molecular Formula: C₁₆H₁₄F₃NO₄S
• Molecular Weight: 373.353
• Mol file: 1610862-28-6.mol

Synonyms:benzyl 5-(methylsulfonamido)-2-(trifluoromethyl)benzoate

Chemical Property of benzyl 5-(methylsulfonamido)-2-(trifluoromethyl)benzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of benzyl 5-(methylsulfonamido)-2-(trifluoromethyl)benzoate

There total 4 articles about benzyl 5-(methylsulfonamido)-2-(trifluoromethyl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

benzyl 5-amino-2-(trifluoromethyl)benzoate (1610862-29-7) + methanesulfonyl chloride (124-63-0) → benzyl 5-(methylsulfonamido)-2-(trifluoromethyl)benzoate (1610862-28-6)

Guidance literature:

With pyridine; at 0 - 20 ℃;

Reference yield:

2-methyl-4-nitro-1-(trifluoromethyl)benzene (1960-52-7) → benzyl 5-(methylsulfonamido)-2-(trifluoromethyl)benzoate (1610862-28-6)

Guidance literature:

Multi-step reaction with 4 steps

1: periodic acid; chromium(VI) oxide / acetonitrile / 20 °C

2: caesium carbonate / acetonitrile / 0.5 h / 100 °C / Microwave irradiation

3: ammonium chloride; iron / water; ethanol / 1 h / 80 °C

4: pyridine / 0 - 20 °C

With pyridine; chromium(VI) oxide; iron; ammonium chloride; caesium carbonate; periodic acid; In ethanol; water; acetonitrile;

Reference yield:

5-nitro-2-(trifluoromethyl)benzoic acid (847547-06-2) → benzyl 5-(methylsulfonamido)-2-(trifluoromethyl)benzoate (1610862-28-6)

Guidance literature:

Multi-step reaction with 3 steps

1: caesium carbonate / acetonitrile / 0.5 h / 100 °C / Microwave irradiation

2: ammonium chloride; iron / water; ethanol / 1 h / 80 °C

3: pyridine / 0 - 20 °C

With pyridine; iron; ammonium chloride; caesium carbonate; In ethanol; water; acetonitrile;

upstream raw materials:

2-methyl-4-nitro-1-(trifluoromethyl)benzene

5-nitro-2-(trifluoromethyl)benzoic acid

benzyl 5-nitro-2-(trifluoromethyl)benzoate

benzyl 5-amino-2-(trifluoromethyl)benzoate

Downstream raw materials:

benzyl 5-(N-(2-morpholinoethyl)methylsulfonamido)-2-(trifluoromethyl)benzoate

C₃₃H₃₄Cl₂F₅N₃O₈S

5-(N-(2-morpholinoethyl)methylsulfonamido)-2-(trifluoromethyl)benzoic acid

Refernces