Technology Process of 1-benzyl-3-methyl-4-hydroxy-4-(5-fluorobenzofuran-7-yl)-piperidine
There total 3 articles about 1-benzyl-3-methyl-4-hydroxy-4-(5-fluorobenzofuran-7-yl)-piperidine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
5-fluoro-7-bromo-benzo(b)furan;
With
magnesium;
In
diethyl ether;
for 0.5h;
Heating / reflux;
1-Benzyl-3-methyl-4-piperidon;
In
tetrahydrofuran; diethyl ether;
for 24h;
Heating / reflux;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: potassium carbonate / DMF (N,N-dimethyl-formamide) / 18 h / Heating / reflux
2.1: amberlyst-15 / chlorobenzene / Heating / reflux; water removal by azeotropic distillation
3.1: magnesium / diethyl ether / 0.5 h / Heating / reflux
3.2: 24 h / Heating / reflux
With
amberlyst-15; potassium carbonate; magnesium;
In
DMF (N,N-dimethyl-formamide); diethyl ether; chlorobenzene;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: amberlyst-15 / chlorobenzene / Heating / reflux; water removal by azeotropic distillation
2.1: magnesium / diethyl ether / 0.5 h / Heating / reflux
2.2: 24 h / Heating / reflux
With
amberlyst-15; magnesium;
In
diethyl ether; chlorobenzene;